Abstract
We present here in the case of a patient who underwent resection of clear cell carcinoma of the lung, a rare histological type. A screening test of the 71-yearold woman revealed a 2.0-cm lesion in S4 of the right lung with a diagnosis of bronchioloalveolar carcinoma before resection. Under the guidance of video-assisted thoracoscopy, right middle lobe resection and mediastinal lymph node dissection were performed. The histopathological examination showed clear, slightly acidophilic tumor cells rich in fine granular components proliferating in an alveolar fashion. Immunostaining was diagnostically useful, distinguishing clear cell carcinoma from lung metastasis of renal clear cell carcinoma or clear cell squamous cell carcinoma.
Similar content being viewed by others
References
Travis WD, Brambilia E, Muller-Hermelink HK, Harris CC. World Health Organization classification of tumors. In: Pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: International Agency for Research on Cancer (IARC) Press; 2004.
Katzenstein ALA, Prioleau PG, Askin FB. The histologic spectrum and significance of clear-cell change in lung carcinoma. Cancer 1980;45:943–947.
Morgan AD, Mackenzie DH. Clear cell carcinoma of the lung. J Pathol Bacteriol 1964;87:25–27.
Yamamoto T, Yazawa T, Ogata T, Akaogi E, Mitsui K. Clear cell carcinoma of the lung: a case report and review of the literature. Lung Cancer 1993;10:101–106.
Inase N, Takayama S, Nakayama M, Miura H, Kimula Y. Pulmonary clear cell carcinoma. J Surg Oncol 1991;48:145–147.
Garzon JC, Lai FM, Mok TSK, Manlulu AV, Ng CS, Lee TW, et al. Clear cell carcinoma of the lung revisited. J Thorac Cardiovasc Surg 2005;130:1198–1199.
Graffey MJ, Mills SE, Askins FB, Ross GW, Sale GE, Kulander BG, et al. Clear cell tumor of the lung: a clinicopathologic, immunohistochemical and ultrastructural study of eight cases. Am J Surg Pathol 1990;14:248–252.
Makishi S, Kinjo T, Sawada S, Chinen K, Hirayasu T, Hamada T, et al. Morules and morule-like features associated with carcinomas in various organs; report with immunohistochemical and molecular studies. J Clin Pathol 2006;59:95–100.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kitada, M., Ozawa, K., Sato, K. et al. Clear cell carcinoma of the lung. Gen Thorac Cardiovasc Surg 58, 87–90 (2010). https://doi.org/10.1007/s11748-009-0471-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11748-009-0471-8