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Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model

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Abstract

Background

Gastric restrictive procedures are considered effective weight loss treatment for severe obesity. The aim of the study was to evaluate the efficacy and safety of a reversible implant that renders a partial restriction of stomach in a canine model.

Methods

The device was comprised of two longitudinal parallel non-compressive plates with two C-rings to create a small gastric pouch that opposed gastric distension. Three groups of non-obese mongrel dogs were included: group I (n = 6) underwent surgical implant for 6 weeks, group II (n = 6) underwent surgical implant for 6 weeks, followed by surgical removal of the implant and additional monitoring for 5 weeks, and group III (n = 5) served as sham-operated controls for groups I and II. Food intake and body weight were monitored, and the stomachs were examined histologically postmortem.

Results

The average food intake was significantly decreased by 38.2% in group I as compared to group III throughout the 6 weeks of surgical implant (P < 0.05). The implanted dogs showed a progressive weight loss as compared to sham, which reached 21% by the end of 6 weeks. In group II, after 5 weeks of implant removal, the body weights recovered to approximately 96% of baseline. Histological evidence of the implant site at the gastric walls revealed no significant structural changes, tissue ischemia, hemorrhage, or necrosis.

Conclusion

Our results validate the feasibility of a reversible gastric restriction implant in a non-obese canine model, with the potential for achieving significant weight loss within 6 weeks and with no injury to the gastric wall.

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Acknowledgment

This research was funded by GRest, Inc. and NIH SBIR Phase I grant R43DK083889. We wish to thank Mr. Mitchell L Keel and Mark Svendsen for excellent technical assistance.

Disclosures

GSK is founder of GRest, Inc. There are no other conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Indiana University–Purdue University Indianapolis, Indianapolis, IN, 46202, USA

    Xiaomei Guo, Hai Zheng, Xiao Lu & Ghassan Kassab

  2. Department of Surgery, IUPUI, Indianapolis, IN, USA

    Samer G. Mattar & Ghassan Kassab

  3. Department of Pathology, IUPUI, Indianapolis, IN, USA

    George Sandusky

  4. Department of Surgery, Austral University, Buenos Aires, Argentina

    Jose A. Navia

  5. Cellular and Integrative Physiology, IUPUI, Indianapolis, IN, USA

    Ghassan Kassab

Authors
  1. Xiaomei Guo
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  2. Hai Zheng
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  3. Samer G. Mattar
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  4. Xiao Lu
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  5. George Sandusky
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  6. Jose A. Navia
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  7. Ghassan Kassab
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Corresponding author

Correspondence to Ghassan Kassab.

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Guo, X., Zheng, H., Mattar, S.G. et al. Reversible Gastric Restriction Implant: Safety and Efficacy in a Canine Model. OBES SURG 21, 1444–1450 (2011). https://doi.org/10.1007/s11695-010-0299-4

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  • DOI: https://doi.org/10.1007/s11695-010-0299-4

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