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Preliminary study of positron emission tomography/computed tomography and plasma osteopontin levels in patients with asbestos-related pleural disease

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Abstract

Purpose

The aim of this study was to compare the results of semiquantitative analysis by18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) with plasma osteopontin levels in the same asbestos-related pleural disease population.

Materials and methods

A total of 17 patients with asbestos-related pleural disease were prospectively recruited. They underwent PET/CT, and plasma osteopontin levels were measured. The maximum standardized uptake value (SUVmax) was determined from the most active pleural lesion in each patient.

Results

Malignant pleural mesothelioma (MPM) was histologically proven in 6 patients, and 11 patients had proven benign asbestos-related pleural diseases (7 pleural plaques, 4 asbestos pleurisy). Significant differences in SUVmax were found between patients with MPM and those with asbestos pleurisy (P = 0.031) and between patients with MPM and those with pleural plaques (P = 0.012). A significant difference was found in the plasma osteopontin levels between patients with asbestos pleurisy and patients with pleural plaques (Bonferroni correction, P = 0.024). The SUVmax in patients with benign asbestos-related diseases was statistically positively correlated with plasma osteopontin in the same group (Spearman’s r = 0.75, P < 0.05).

Conclusion

PET/CT might be more helpful than plasma osteopontin for distinguishing benign asbestos-related pleural diseases from MPM, and the SUVmax in benign asbestos-related pleural diseases may reflect changes in pleural inflammation.

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Authors and Affiliations

  1. Division of Nuclear Medicine and PET Center, Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan

    Seiji Kurata, Masatoshi Ishibashi, Hayato Kaida, Maiko Kobayashi & Yasumitsu Hirose

  2. Division of Respiratory, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan

    Koichi Azuma & Hisamichi Aizawa

  3. Department of Surgery, Kurume University School of Medicine, Kurume, Japan

    Shinzo Takamori

  4. Department of Radiology, Kurume University School of Medicine and Center for Diagnostic Imaging, Kurume University Hospital, Kurume, Japan

    Kiminori Fujimoto & Naofumi Hayabuchi

Authors
  1. Seiji Kurata
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  2. Masatoshi Ishibashi
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  3. Koichi Azuma
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  4. Hayato Kaida
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  5. Shinzo Takamori
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  6. Kiminori Fujimoto
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  7. Maiko Kobayashi
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  8. Yasumitsu Hirose
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  9. Hisamichi Aizawa
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  10. Naofumi Hayabuchi
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Corresponding author

Correspondence to Seiji Kurata.

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Kurata, S., Ishibashi, M., Azuma, K. et al. Preliminary study of positron emission tomography/computed tomography and plasma osteopontin levels in patients with asbestos-related pleural disease. Jpn J Radiol 28, 446–452 (2010). https://doi.org/10.1007/s11604-010-0449-6

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  • DOI: https://doi.org/10.1007/s11604-010-0449-6

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