Abstract
During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1. However, AIDS progression in the former blood donors (FBDs) is various. The aim of this study is to assess human leukocyte antigen (HLA) class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART naïve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared with HIV-seropositive group, the frequency of HLA-A*03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes, detrimental effect of HLA Bw6/ Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. This study provides novel evidence on HLA class I allele distribution and association of HLA-A*03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression.
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Bacchetti P, Moss A R. Incubation period of AIDS in San Francisco. Nature, 1998, 338: 251–253
Hessol N A, Koblin B A, van Griensven G J, et al. Progression of human immunodeficiency virus type 1 (HIV-1) infection among homosexual men in hepatitis B vaccine trial cohorts in Amsterdam, New York City, and San Francisco, 1978–1991. Am J Epidemiol, 1994, 139: 1077–1087
Muñoz A, Wang M C, Bass S, et al. Acquired immunodeficiency syndrome (AIDS)-free time after human immunodeficiency virus type 1 (HIV-1) seroconversion in homosexual men. Am J Epidemiol, 1989, 130: 530–539
Hendriks J C, Medley G F, van Griensven G J, et al. The treatment-free incubation period of AIDS in a cohort of homosexual men. AIDS, 1993, 7: 231–239
Haynes B F, Pantaleo G, Fauci A S. Toward an understanding of the correlates of protective immunity to HIV infection. Science, 1996, 271: 324–328
Baker E, Machewicz C E, Reyes-Teran G, et al. Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome. Blood, 1998, 92: 3105–3114
Deeks S G, Walker B D. Human immunodeficiency virus controllers: Mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity, 2007, 27: 406–416
Walker B D. Elite control of HIV Infection: implications for vaccines and treatment. Top HIV Med, 2007, 15: 134–136
Gray R H, Wawer M J, Brookmeyer R, et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda. Lancet, 2001, 357: 1149–1153
Darby S C, Ewart D W, Giangrande P L, et al. Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. Lancet, 1996, 347: 1573–1579
Operskalski E A, Stram D O, Lee H, et al. Human immunodeficiency virus type 1 infection: Relationship of risk group and age to rate of progression to AIDS. J Infect Dis, 1995, 172: 648–655
Farzadegan H, Hoover D R, Astemborski J, et al. Sex differences in HIV-1 viral load and progression to AIDS. Lancet, 1998, 352: 1510–1514
Sterling T R, Vlahov D, Astemborski J, et al. Initial plasma HIV-1 RNA levels and progression to AIDS in women and men. N Engl J Med, 2001, 344: 720–725
Carrington M, O’Brien S J. The influence of HLA genotype on AIDS. Annu Rev Med, 2003, 54: 535–551
Roger M. Influence of host genes on HIV-1 disease progression. FASEB J, 1998, 12: 625–632
Meier U C, Owen R E, Taylor E, et al. Shared alterations in NK cell frequency, phenotype, and function in chronic human immunodeficiency virus and hepatitis C virus infections. J Virol, 2005, 79: 12365–12374
Fauci A S, Mavilio D, Kottilil S. NK cells in HIV infection: Paradigm for protection or targets for ambush. Nat Rev Immunol, 2005, 5: 835–844
Mavillio D, Benjamin J, Daucher M, et al. Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates. Proc Natl Acad Sci USA, 2003, 100: 15011–15016
Wang S H, Xing H, Wang J J, et al. Sequence analysis of gag and env genes of HIV type 1 circulating in former blood donors of Fuyang city, Anhui province. Natl Med J China, 2007, 87: 1535–1539
Lewis C M. Genetic association studies: Design, analysis and interpretation. Brief Bioinform, 2002, 3: 146–153
Xu C, Chen Q W, Ding X P. On HIV scanning and infectious condition of former blood donors in Fuyang city. Chin Rural Health Service Admin, 2006, 26: 44–46
Zhai S, Zhuang Y, Song Y, et al. HIV-1-specific cytotoxic T lymphocyte (CTL) responses against immunodominant optimal epitopes slow the progression of AIDS in China. Curr HIV Res, 2008, 6: 335–350
Gao X, Nelson G W, Karacki P, et al. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med, 2001, 344: 1668–1675
Li S, Jiao H, Yu X, et al. Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort. J Acquir Immue Defic Syndr, 2007, 44: 121–131
Racape J, Connan F, Hoebeke J, et al. Influence of dominant HIV-1 epitopes on HLA-A3/peptide complex formation. Proc Natl Acad Sci USA, 2006, 103: 18208–18213
Lichterfeld M, Williams K L, Mui S K, et al. T cell receptor crossrecognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. Int Immunol, 2006, 18: 1179–1188
Flores-Villanueva P O, Yunis E J, Delgado J C, et al. Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity. Proc Natl Acad Sci USA, 2001, 98: 5140–5145
Qing M, Li T, Han Y, et al. Accelerating effect of human leukocyte antigen-Bw6 homozygosity on disease progression in Chinese HIV-1-infected patients. J Acquir Immue Defic Syndr, 2006, 41: 137–139
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Zhang, W., Wang, L., Hong, K. et al. Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort. Sci. China Life Sci. 56, 1014–1019 (2013). https://doi.org/10.1007/s11427-013-4555-4
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DOI: https://doi.org/10.1007/s11427-013-4555-4