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New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(II)-arene complex

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Abstract

Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.

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Authors and Affiliations

  1. State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, China

    ShuiHong Li, ChangYu Wu, ShengPing Gao & XueMei Wang

  2. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

    Xiao Tang & Hong Yan

  3. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China

    XinQing Zhao

Authors
  1. ShuiHong Li
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  2. ChangYu Wu
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  3. Xiao Tang
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  6. Hong Yan
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  7. XueMei Wang
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Correspondence to XueMei Wang.

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Li, S., Wu, C., Tang, X. et al. New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(II)-arene complex. Sci. China Chem. 56, 595–603 (2013). https://doi.org/10.1007/s11426-012-4812-6

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  • DOI: https://doi.org/10.1007/s11426-012-4812-6

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