Abstract
Background
Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.
Methods
In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 ± 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.
Results
Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R 2 of the model was 0.486.
Conclusion
Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.
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Acknowledgments
The authors thank all the patients and staff of the Division of Nephrology. This work was funded by a grant from the hospital PhD MD researching grant, program of First Affiliated Hospital of Kunming Medical University (2007bs08), by a Science and Technology Key Projects Grant Kunming Science and Technology Bureau (08S090104), and by a grant from the Social Development Science and Technology Department of Yunnan Province (2008ZC127 M). TW was supported by a grant from the Cheung Kong Scholar Programme, Ministry of Education, People’s Republic of China (36-1); a National “211 project” Grant to Peking University EBM group (38-18); a Grant from Doctoral Degree Fund (Ministry of Education, People’s Republic of China BSD-06-5-24); and by a grant from the Clinical Research Program (Peking University Third Hospital YLZD 06-5-27).
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None of the authors declare any conflicts of interest.
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Bai, Y., Xiao, H., Liu, Z. et al. Increased night heart rate is associated with worse large artery elasticity in chronic kidney disease patients. Int Urol Nephrol 45, 1621–1627 (2013). https://doi.org/10.1007/s11255-013-0431-1
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DOI: https://doi.org/10.1007/s11255-013-0431-1