Abstract
Bovine tuberculosis (BTB), a chronic disease caused by Mycobacterium bovis, has been widely reported in bovines in developing countries, but there is little information on this infection in domestic yaks. Seroprevalence of antibodies to M. bovis in yaks from six and three regions of Tibet and Qinghai plateau, China, respectively, was investigated in 2011 by enzyme-linked immunosorbent assay kits. A total of 1,244 (Tibet 938, Qinghai 306) blood samples was collected and the results showed that 24 (2.6 %) of Tibetan samples and 3 (1 %) of Qinghai's samples were positive for BTB. The findings of the present study indicated that M. bovis infection is prevalent in Chinese yaks in Qinghai and Tibet. These observations should raise a serious public health concern considering the extent to which the herdsmen of the study areas are in contact with their animals and the levels at which they use untreated livestock products. This is the first study showing the infection of M. bovis in domestic yaks.
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Awah-Ndukum, J., Kudi, A.C., Bah, G.S., Bradley, G., Tebug, S.F., Dickmu, P.L., Njakoi, H.N., Agharih, W.N., 2012. Bovine tuberculosis in cattle in the highlands of Cameroon: seroprevalence estimates and rates of tuberculin skin test reactors at modified cut-offs. Veterinary Medicine International, doi:10.1155/2012/798502
Ayele, W.Y., Neill, S.D., Zinsstag, J., Weiss, M.G., Pavlik, I., 2004. Bovine tuberculosis: an old disease but a new threat to Africa. The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease 8(8), 924–37
Biet, F., Boschiroli, M.L., Thorel, M.F., Guilloteau, L.A., 2005. Zoonotic aspects of Mycobacterium bovis and Mycobacterium avium-intracellulare complex (MAC). Veterinary Research 36 (3), 411–36
Boadella, M., Lyashchenko, K., Greenwald, R., Esfandiari, J., Jaroso, R., Carta, T., Garrido, J.M., Vicente, J., de, la, Fuente, J., Gortázar, C., 2011. Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies. J Vet Diagn Invest. 23(1):77–83
Cleaveland, S., Shaw, D.J., Mfinanga, S.G., Shirima, G., Kazwala, R.R., Eblate, E., Sharp, M., 2007. Mycobacterium bovis in rural Tanzania: Risk factors for infection in human and cattle populations, Tuberculosis, 87: 30–43
Cosivi, O., Grange, J.M., Daborn, C.J., Raviglione, M.C., Fujikura, T., Cousins, D., Robinson, R.A., Huchzermeyer, H.F., de, Kantor, I., Meslin, F.X., 1998. Zoonotic tuberculosis due to Mycobacterium bovis in developing countries, Emerging Infectious Diseases, 4, 59–70
Gao, J.F., Liu, M.Y., Meng, X.R., Han, Z.Q., Zhang, D., Hou, B., Zhang, K.R., Sizhu, S.L., Li, J.K., 2012. Seroprevalence of bovine viral diarrhea infection in Yaks (Bos grunniens) on the Qinghai-Tibetan Plateau of China. Tropical Animal Health and Production doi:10.1007/s11250-012-0290-2
Gumi, B., Schelling, E., Firdessa, R., Erenso, G., Biffa, D., Aseffa, A., Tschopp, R., Yamuah, L., Young, D., Zinsstag, J., 2012. Low prevalence of bovine tuberculosis in Somali pastoral livestock, southeast Ethiopia. Tropical Animal Health and Production 44(7), 1445–50
Khan, I.A., Khan, A., Mubarak, A., Ali, A., 2008. Factors affecting prevalence of bovine tuberculosis in Nili Ravi buffaloes, Pakistan Veterinary Journal, 28(4): 155–158
Lamichhaney, S., (2010) Prevalence and Risk Factor Assessment of Bovine Tuberculosis: Impact of the disease in wildlife, domestic animals and human interface at Koshi Tappu Wildlife Reserve in Eastern Nepal. Lambert Academic Publishing, Saarbrücken, Germany
Lang X.L., Qu, H.L., Bu, Z.Y., Yang, Y.L., Sun, C.H., Li, X.Y., Wang, J.L., Cai, J.S., Ma, R.L., Fu, Y.J., Wang, X.L., 2011. Seroprevalence of Brucella infection in yaks (Bos grunniens) on the Qinghai-Tibet plateau of China, Tropical Animal Health and Production, 43: 305–306
Liu, J., Cai, J.Z., Zhang, W., Liu, Q., Chen, D., Han, J.P., Liu, Q.R., 2008. Seroepidemiology of Neospora caninum and Toxoplasma gondii infection in yaks (Bos grunniens) in Qinghai, China, Veterinary Parasitology, 152, 330–332
OIE, 2009. Office International des Epizooties Terrestrial manual: Chapter 2.4.7, World Health Organization for Animal Health, Paris
Schiller, I., Vordermeier, H.M., Waters, W.R., Whelan, A.O., Coad, M., Gormley, E., Buddle, B.M., Palmer, M., Thacker, T., McNair, J., Welsh, M., Hewinson, R.G., Oesch, B., 2010. Bovine tuberculosis: Effect of the tuberculin skin test on in vitro interferon gamma responses. Veterinary Immunology and Immunopathology 136(1–2), 1–11
Tschopp, R., Aseffa, A., Schelling, E., Berg, S., Hailu, E., Gadisa, E., Habtamu, M., Argaw, K., Zinsstag, J., 2010. Bovine tuberculosis at the wildlife-livestock-human interface in Hamer Woreda, South Omo, Southern Ethiopia. PLoS One, 17: 5–8
Zhang, L.X., Sun, Y., Yang, L., Li, G.L., 2011. Epidemic situation of tuberculosis in Tibet, Journal of Clinical Pulmonary Medicine, 16: 1268–1269
Zinsstag, J., Schelling, E., Roth, F. and Kazwala, R., 2006. Economics of Bovine Tuberculosis. In: Thoen, C.O., Steele, J.H., Gilsdorf, M.J. (2nd eds), Mycobacterium bovis infection in animals and humans. Blackwell, Boston
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This study was supported by the Tibet Autonomous Region Science Fund and the Chinese Agricultural Research Systems (CARS-38).
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Zhaoqing Han and Jianfeng Gao contributed equally to this study.
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Han, Z., Gao, J., Shahzad, M. et al. Seroprevalence of bovine tuberculosis infection in yaks (Bos grunniens) on the Qinghai-Tibetan Plateau of China. Trop Anim Health Prod 45, 1277–1279 (2013). https://doi.org/10.1007/s11250-013-0354-y
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DOI: https://doi.org/10.1007/s11250-013-0354-y