Cognitive impairments in patients with Parkinson’s disease (PD) lead to occupational, social, and psychological maladaptation of patients and their relatives. This article presents the epidemiology, structure, and nature of cognitive impairments in PD; the main pathogenetic factors involved in the development of moderate cognitive impairment and dementia in PD are discussed, as are the methods of diagnosis and assessment of cognitive impairments and approaches to the correction of memory and intellectual impairments. Results obtained from our own studies of the effects of treatment with amantadine sulfate at a dose of 300 mg for 6 months on changes in cognitive impairments in 25 patients with PD are presented. Treatment results were evaluated using neuropsychological questionnaire and scales (Mini Mental State Evaluation, Frontal Assessment Battery, Matiss Dementia Rating Scale). In patients with PD and moderate cognitive impairments, six months of treatment with amantadine sulfate produced significant improvements in neuropsychological test results.
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R. K. Arakelyan, E. A. Nerobkova, and E. A. Katunina, “Functional activity of the brain in patients with Parkinson’s disease during treatment with amantadine sulfate,” Zh. Nevrol. Psikhiat., 4 (2005).
D. V. Artemiev and Zh. M. Glozman, “Impairments to higher mental functions in Parkinson’s disease,” in: Progress in Neurogeriatrics [in Russian], N. N. Yakhno and I. V. Damulin (eds.), Moscow (1995), Vol. 1, pp. 46–58.
I. V. Damulin, Dementia in Parkinson’s Disease. Advice for Physicians [in Russian], Moscow (2005).
V. V. Zakharov, “Dementia in Parkinson’s disease,” Nevrol. Zh., Addendum 1, 11, 13–18 (2006).
V. V. Zakharov, Impairments to Cognitive Functions in Parkinson’s Disease and Symptomatic Parkinsonism [in Russian], Author’s Abstract of Doctoral Thesis in Medical Sciences, Moscow (2003), pp. 36–40.
V. V. Zakharov, P. V. Yaroslavtseva, and N. N. Yakhno, “Cognitive impairments in Parkinson’s disease,” Nevrol. Zh., 2, 11–13 (2003).
V. V. Zakharov and N. N. Yakhno, “Moderate cognitive impairment in the elderly: diagnosis and treatment,” Rus. Med. Zh., 10, 573–576 (2004).
O. S. Levin, L. A. Batukaeva, and I. G. Smolentseva, “Diagnosis and treatment of dementia in Parkinson’s disease,” Zh. Nevrol. Psikhiat., 6, 91–97 (2008).
O. S. Levin and L. V. Golubeva, “Heterogeneity of moderate cognitive impairment: diagnostic and therapeutic aspects,” Konsilium, 12, 106–110 (2006).
ICD-10. International Classification of Diseases and Health- Related Problems [Russian translation], 10th edition, Vol. 1, WHO, Geneva (1995).
A. A. Pilipovich and V. L. Golubev, “Effects of Pronoran on cognitive and affective impairments in Parkinson’s disease,” Zh. Nevrol. Psikhiat., 4, 41–47 (2005).
A. N. Sadikova, Correction of Clinical, Neuropsychological, and Computerized Tomography Data in Parkinson’s Disease [in Russian], Author’s Abstract of Master’s Thesis in Medical Sciences, Moscow (1977).
A. D. Stepkina, V. V. Zakharov, and N. N. Yakhno, “Cognitive impairments on progression of Parkinson’s disease,” Zh. Nevrol. Psikhiat., 10, 13–19 (2005).
N. N. Yakhno, Cognitive impairments in the neurology clinic,” Nevrol. Zh., Addendum 1, 11, 4–12 (2006).
A. L. Benton, N. R. Varney, and K. Hamsher, “Visuospatial judgement: a clinical test,” Arch. Neurol., 35, 364–367 (1978).
K. Bronnick, M. Emre, R. Lane, et al., “Profile of cognitive impairment in dementia associated with Parkinson’s disease compared with Alzheimer’s disease,” J. Neurol. Neurosurg. Psychiat., 78, 1064–1068 (2007).
P. Caspar, C. Duyckaerts, et al., “Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson’s disease,” Ann. Neurol., 30, 365–374 (1991).
J. L. Cummings, “Cholinesterase inhibitors for treatment of dementia associated with Parkinson’s disease,” J. Neurol. Neurosurg. Psychiat., 76, 903–904 (2005).
B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, “The FAB: a frontal assessment battery at bedside,” Neurology, 55, 1621–1626 (2000).
M. Emre, D. Aarsland, R. Brown, et al., “Clinical diagnostic criteria for dementia associated with Parkinson’s disease,” Mov. Dis., 22, 1689–1707 (2007).
M. Emre, “Dementia associated with Parkinson’s disease,” Lancet Neurol., 2, 229–237 (2003).
S. Fahn and R. Eiton, Unified Parkinson’s Disease Rating Scale. Recent Developments in Parkinson’s Disease, S. Fahn, C. Marsden, and D. Calne (eds.), McMillan Healthcare Information (1987), Vol. 5, pp. 153–163.
M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Mini Mental State: a practical guide for grading the mental state of patients for the clinician,” J. Psychiatr. Res., 12, 189–198 (1975).
J. E. Galvin, J. Pollack, and J. C. Morris, “Clinical phenotype of Parkinson Disease dementia,” Neurology, 67, 1605–1611 (2006).
G. Gianutsos, S Chute, and J. P. Dunne, “Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine,” Eur. J. Pharmacol., 110, 357–361 (1985).
J. Golomb, A. Kluger, and S. H. Ferris, Clinician’s Manual on Mild Cognitive Impairment, Science Press, London (2001).
P. Hobson and J. Meara, “Risk and incidence of dementia in a cohort of older subjects with Parkinson’s disease in the United Kingdom,” Mov. Dis., 19, 1043–1049 (2004).
M. Hoehn and M. D. Yahr, “Parkinsonism: onset, progression and mortality,” Neurology, 17, No. 5, 427–442 (1967).
R. Inzelberg, U. Bonuccelli, et al., “Association between amantadine and the onset of dementia in Parkinson’s disease,” Mov. Dis., 2, No. 9, 1375–1379 (2006).
D. M. Jacobs, K. Marder, L. Cote, et al., “Neuropsychological characteristics of preclinical dementia in Parkinson’s disease,” Neurology, 45, 1691–1696 (1995).
J. Kaplan, H. Goodglass, and S. Weintraub, The Boston Naming Test, Boston (1978).
P. L. Le Bars, M. M. Katz, and N. A. Berman, “Placebo-controlled, double-blind, randomized trial of an extract of Gingko biloba for dementia,” J. Am. Med. Assoc., 278, 1327–1332 (1997).
G. Lewy and D. M. Jacobs, “Memory and executive function impairments predict dementia in Parkinson’s disease,” Mov. Dis., 17, No. 6, 1221–1226 (2002).
M. D. Lezak, Neuropsychology Assessment, New York University Press, New York (1983).
M. A. Malone, K. Jerchner, and J. M. Swanson, “Hemispheric processing and methylphenidate effects in attention deficit hyperactivity disorder,” J. Child Neurol., 9, No. 2, 181 (1997).
K. Marder, M. Z. Tang, L. Cote, and Y. Stern, “The frequency and associated risk factors for dementia in patients with Parkinson’s disease,” Arch. Neurol., 52, 695–701 (1995).
S. Mattis, “Mental state examination for organic mental syndrome in the elderly patient,” in: Geriatric Psychiatry, L. Bellack and T. B. Karasu (eds.), New York (1976).
K. Palmer,V. Jelic, and B. Winblad, “Preface: mild cognitive impairment,” Acta Neurol. Scand., 107, Supplement 179, 5–6 (2003).
R. F. Peppard. W. R. Martin, G. D. Carr, et al., “Cerebral glucose metabolism in Parkinson’s disease with and without dementia,” Arch. Neurol., 49, 1262–1268 (1992).
R. S. Peterson, G. E. Smith, S. C. Waring, et al., “Mild cognitive impairment: clinical characterization and outcome,” Arch. Neurol., 56, 303–308 (1999).
R. S. Peterson and J. Touchon, “Consensus on mild cognitive impairment,” Res. Pract. Alzheimer’s Dis., 10, 24–32 (2005).
W. Poewe, E. Wolters, M. Emre, et al., “Long-term benefits of rivastigmine in dementia associated with Parkinson’s disease: an active treatment extension study,” Mov. Dis., 21, No. 4, 456–461 (2006).
P. R. von Voigtlander and K. E. Moore, “Dopamine release from the brain in vivo by amantadine,” Science, 174, 408–410 (1937).
A. R. Young et al., in: Excitatory Amino Acids and Synaptic Transmission, Academic Press Harcourt Brace and Co., New York, pp. 29–40.
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 110, No. 7, pp. 24–30, July, 2010.
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Yablonskaya, A.Y., Fedorova, N.V. & Belgusheva, M.E. Effects of Amantadine Sulfate on Cognitive Impairments in Patients with Parkinson’s Disease. Neurosci Behav Physi 41, 567–573 (2011). https://doi.org/10.1007/s11055-011-9456-z
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DOI: https://doi.org/10.1007/s11055-011-9456-z