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Hydrophobic polymers modification of mesoporous silica with large pore size for drug release

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Abstract

Mesostructure cellular foam (MCF) materials were modified with hydrophobic polyisoprene (PI) through free radical polymerization in the pores network, and the resulting materials (MCF-PI) were investigated as matrices for drug storage. The successful synthesis of PI inside MCF was characterized by Fourier transform infrared (FT-IR), hydrogen nuclear magnetic resonance (1H NMR), X-ray diffraction patterns (XRD) and nitrogen adsorption/desorption measurements. It was interesting to find the resultant system held a relatively large pore size (19.5 nm) and pore volume (1.02 cm3 g−1), which would benefit for drug storage. Ibuprofen (IBU) and vancomycin were selected as model drugs and loaded onto unmodified MCF and modified MCF (MCF-PI). The adsorption capacities of these model drugs on MCF-PI were observed increase as compared to that of on pure MCF, due to the trap effects induced by polyisoprene chains inside the pores. The delivery system of MCF-PI was found to be more favorable for the adsorption of IBU (31 wt%, IBU/silica), possibly attributing to the hydrophobic interaction between IBU and PI formed on the internal surface of MCF matrix. The release of drug through the porous network was investigated by measuring uptake and release of IBU.

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Acknowledgements

The authors greatly acknowledge the financial support of this research by the National Science Foundation of China (Nos. 50573013, 50772067) Shanghai Science and Technology Committee (Nos. 05ZR14077, 06PJ14063, 07DJ14001), the Scientific Research Foundation for the Returned Overseas Chinese Scholars (State Education Ministry). The authors thank SJTU Instrument Analysis Center for the measurements.

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Authors and Affiliations

  1. State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, P.R. China

    Shenmin Zhu

  2. Key Lab of Molecular Engineering of Polymers, Fudan University, Ministry of Education, Shanghai, P.R. China

    Di Zhang & Na Yang

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  1. Shenmin Zhu
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  2. Di Zhang
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  3. Na Yang
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Correspondence to Shenmin Zhu.

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Zhu, S., Zhang, D. & Yang, N. Hydrophobic polymers modification of mesoporous silica with large pore size for drug release. J Nanopart Res 11, 561–568 (2009). https://doi.org/10.1007/s11051-007-9325-4

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  • DOI: https://doi.org/10.1007/s11051-007-9325-4

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