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Ectopic expression of micro-RNA-1, 21 and 125a in peripheral blood immune cells is associated with chronic HBV infection

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Abstract

Micro-RNAs (miRNAs) play key roles in regulating genes of the immune system. The aim of this study was to examine the expression of miR-1, 21 and 125a in the immune cells taken from the peripheral blood of patients suffering from chronic HBV infection (CHB). This cross-sectional study was performed on 60 CHB patients and 60 healthy controls and expression of miR-1, 21 and 125a was evaluated using quantitative Real-Time PCR. The results showed that expression of miR-1, 21 and 125a was significantly increased in CHB patients in comparison to healthy controls. Based on our results it may be concluded that increased expression of miR-1, 21 and 125a is significantly associated with CHB and may play key roles in the induction of impaired immune responses in CHB patients.

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Acknowledgments

Authors of this article would like to take this opportunity to thank all of the participants who co-operated in this project. This project was supported by a Grant from the Rafsanjan University of Medical Sciences.

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Authors and Affiliations

  1. Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Mohammad Momeni & Mohammad Kazemi Arababadi

  2. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Gholamhossein Hassanshahi

  3. School of Natural Sciences, Eskitis Institute for Drug Discovery, Griffith University Nathan, Nathan, QLD, Australia

    Derek Kennedy

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  1. Mohammad Momeni
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  2. Gholamhossein Hassanshahi
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  3. Mohammad Kazemi Arababadi
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  4. Derek Kennedy
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Correspondence to Mohammad Kazemi Arababadi.

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Momeni, M., Hassanshahi, G., Arababadi, M.K. et al. Ectopic expression of micro-RNA-1, 21 and 125a in peripheral blood immune cells is associated with chronic HBV infection. Mol Biol Rep 41, 4833–4837 (2014). https://doi.org/10.1007/s11033-014-3355-7

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  • DOI: https://doi.org/10.1007/s11033-014-3355-7

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