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TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies

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Abstract

A number of studies have investigated the association between TNF-308 (rs1800629 G/A) polymorphisms and the susceptibility towards tuberculosis (TB) in different populations. However, many of these studies provided inconsistent results. In this study, a systematic review and meta-analysis of the published studies was performed to gain a clearer understanding of this association. The PubMed, Embase, Web of Science and CNKI databases were searched for case–control studies published up to Jan 2011, we used no lower date limit. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. A total of 18 publications from 2001 to 2010, involving 2584 TB cases and 3817 controls were included. Overall, for the A allele carriers (G/A + A/A) vs. homozygote GG, the pooled OR was 1.03 (95% CI = 0.89–1.19; P = 0.912 for heterogeneity). For the allele A vs. allele G, the pooled OR was 1.07 (95% CI = 0.93–1.22; P = 0.013 for heterogeneity). In the stratified analysis by ethnicity, among Asians significant risk was found for allele A vs. allele G (OR = 1.22, 95% CI = 1.02–1.47; P = 0.152 for heterogeneity), no significant risks were found among Caucasians. This meta-analysis indicated that the TNF-308 polymorphism was not associated with the risk of TB in the total population, however the significant risk for TNF-308 A allele was found among Asians not Caucasians.

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Acknowledgments

This study was supported by a grant from the Major Program of Nanjing Medical Science and Technique Development Foundation in 2007 (Molecular Predictor of Personalized Therapy for Chinese Patients with Non-small Cell Lung Cancer) (Lk-Yu).

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The authors declare there are no conflicts of interest in this research.

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Authors and Affiliations

  1. Department of Respiratory Medicine, No. 81 Hospital of PLA, Nanjing, China

    Qin Wang

  2. First Department of Respiratory Medicine, Nanjing Chest Hospital, 215 Guangzhou Road, Nanjing, 210029, China

    Ping Zhan, Qian Qian & Li-Ke Yu

  3. Department of Medical Oncology, Cancer Hospital, Shanghai Medical College, Fudan University, Shanghai, China

    Li-Xin Qiu

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  1. Qin Wang
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  3. Li-Xin Qiu
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Correspondence to Li-Ke Yu.

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Qin Wang, Ping Zhan and Li-Xin Qiu contributed equally to this work and should be considered as co-first authors.

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Wang, Q., Zhan, P., Qiu, LX. et al. TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies. Mol Biol Rep 39, 3393–3400 (2012). https://doi.org/10.1007/s11033-011-1110-x

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