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Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases

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Abstract

The modification of free amino groups on proteins, lipids, and nucleic acids by non-enzymatic glycosylation produce a variety of complex structures named advanced glycation end products (AGEs). Glycation of these molecules participate in the development of diabetic complications and related diseases. Diabetes mellitus is characterized by short-term metabolic changes in lipid and protein metabolism, and long-term irreversible changes in vascular and connective tissue. AGEs are directly implicated in the development of chronic complications in diabetes such as nephropathy, rethinopathy, neuropathy, and other related diseases such as atherosclerosis, heart disease, stroke, and peripheral vascular disease. In this review, we aim to explain how glycation occurs in different molecules and what the pathological consequence of AGE formation in diabetes mellitus and other diseases are.

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Authors and Affiliations

  1. Medical Research Unit in Metabolic Diseases, National Medical Center, Mexican Institute of Social Security, P.O. Box A-047, 06703, Mexico, D.F., Mexico

    José D. Méndez

  2. Department of Cell Physiology and Pharmacology, College of Medicine, Biological Sciences and Psychology, University of Leicester, The Henry Welcome Building, University Road, Leicester, LE1 9HN, UK

    Jianling Xie

  3. Department of Biochemistry, College of Medicine, Biological Sciences and Psychology, University of Leicester, The Henry Welcome Building, University Road, Leicester, LE1 9HN, UK

    Montserrat Aguilar-Hernández

  4. Division of Diabetes, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, USA

    Verna Méndez-Valenzuela

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  1. José D. Méndez
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Méndez, J.D., Xie, J., Aguilar-Hernández, M. et al. Molecular susceptibility to glycation and its implication in diabetes mellitus and related diseases. Mol Cell Biochem 344, 185–193 (2010). https://doi.org/10.1007/s11010-010-0541-3

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