Disease-related worry is associated with family history and perceived risk of that disease; however, the influences of general risk perceptions and tendencies to worry about diseases have been neglected in the literature. This study investigates a model of disease-specific worry which includes family history, disease-specific perceived risk, and perceived risk for and worry about other diseases. Participants completed a survey assessing these variables in relation to several heritable diseases. Structural equation modeling found that family history predicted disease-specific perceived risk but not perceived risk for other diseases. Disease-specific perceived risk predicted disease-specific worry and worry about other diseases. Perceived risk for other diseases predicted worry about other diseases and disease-specific perceived risk but not disease-specific worry. Disease-specific worry predicted worry about other diseases. This model was supported across several diseases and indicates that disease-specific and general considerations of risk influence worry about a disease and should be considered in interventions.
Similar content being viewed by others
REFERENCES
Andersen, M., Smith, R., Meischke, H., Bowen, D., and Urban, N. (2003). Breast cancer worry and mammography use by women with and without a family history in a population-based sample. Cancer Epidemiol. Biomarkers Prev. 12: 314–320.
Baron, R., and Kenny, D. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51: 1173–1182.
Bentler, P. (1990). Comparative fit indexes in structural models. Psychol. Bull. 107: 38–42.
Bentler, P., and Bonnett, D. (1980). Significance tests and goodness of fit in the analysis of covarince structures. Psychol. Bull. 88: 588–606.
Biswas, M., Calhoun, P., Bosworth, H., and Bastian, L. (2002). Are women worrying about heart disease? Women's Health Issu. 12: 204–211.
Bollen, K., and Long, J. (1993). Testing Structural Equation Models, Sage, Newbury Park, CA.
Bowen, D., Hickman, K., and Powers, D. (1997). Importance of psychological variables in understanding risk perceptions and breast cancer screening of African American women. Women's Health Res. Gender Behav. Policy 3: 227–242.
Bratt, O., Damber, J., Emanuelsson, M., Kristoffersson, U., Lundgren, R., Olsson, H., and Gronberg H. (2000). Risk perception, screening practice and interest in genetic testing among unaffected men in families with hereditary prostate cancer. Eur. J. Cancer 36: 235–241.
Brenes, G., and Paskett, E. (2000). Predictors of stage of adoption for colorectal cancer screening. Prev. Med. 31: 410–416.
Browne, M., and Cudek, R. (1993). Alternative ways of assessing model fit. In Bollen, K. A., and Long, J. S. (Eds.), Testing Structural Equation Models, Sage, Newbury Park, CA.
Cohen, L., Fouladi, R. T., Babaian, R. J., Bhadkamkar, V. A., Parker, P. A., Taylor, C. C., Smith, M. A., Gritz, E. R., and Basen-Engquist, K. (2003). Cancer worry is associated with abnormal prostate-specific antigen levels in men participating in a community screening program. Cancer Epidemiol. Biomarkers Prev. 12: 610–617.
Daly, M., Farmer, J., Harrop-Stein, C., Montgomery, S., Itzen, M., Costalas, J., Rogatko, A., Miller, S., Balshem, A., and Gillespie, D. (1999). Exploring family relationships in cancer risk counseling using the genogram. Cancer Epidemiol. Biomarkers Prev. 8: 393–398.
Drossaert, C., Boer, H., and Seydel, E. (1996). Perceived risk, anxiety, mammogram uptake, and breast self-examination of women with a family history of breast cancer: The role of knowing to be at increased risk. Cancer Detect. Prevent. 20: 76–85.
Durfy, S., Bowen, D., McTiernan, A., Sporleder, J., and Burke, W. (1999). Attitudes and interest in genetic testing for breast and ovarian cancer susceptibility in diverse groups of women in western Washington. Cancer Epidemiol. Biomarkers Prev. 8: 369–375.
Erblich, J., Bovbjerg, D., Norman, C. Valdimarsdottir, H., and Montgomery, G. (2000). It won't happen to me: Lower perception of heart disease risk among women with family histories of breast cancer. Prev. Med. 31: 714–721.
Forsyth, L., and Goetsch, V. (1997). Perceived threat of illness and health protective behaviors in offspring of adults with non-insulin-dependent diabetes mellitus. Behav. Med. 23: 112–121.
Friedman, L., Webb, J., Richards, S., and Plon, S. (1999). Psychological and behavioral factors associated with colorectal cancer screening. Prev. Med. 29: 119–125.
Gerend, M., Aiken, L., and West, S. (2004a). Personality factors in older women's perceived susceptibility to diseases of aging. J. Pers. 72: 243–270.
Gerend, M., Aiken, L., West, S., and Erchull, M. (2004b). Beyond medical risk: investigating the psychosocial factors underlying women's perceptions of susceptibility to breast cancer, heart disease, and osteoporosis. Health Psychol. 33: 247–258.
Harwell, T., Dettori, N., Flook, B., Priest, L., Williamson, D., Helgerson, S., and Gohdes, D. (2001). Preventing type 2 diabetes: Perceptions about risk and prevention in a population-based sample of adults > or = 45 years of age. Diabetes Care 24: 2007–2008.
Hay, J., Buckley, T., and Ostroff, J. (2005). The role of cancer worry in cancer screening: a theoretical and empirical review of the literature. Psycho-Oncology 14:517–534.
Joreskog, K., and Sorbom, D. (1996). Lisrel 8: User's Reference Guide, Scientific Software International, Chicago.
Kent, G., Howie, H., Fletcher, M., Newbury-Ecob, R., and Hosie, K. (2000). The relationship between perceived risk, thought intrusiveness and emotional well-being in women receiving counseling for breast cancer risk in a family history clinic. Br. J. Health Psychol. 5: 15–26.
Lerman, C., and Schwartz, M. (1993). Adherence and psychological adjustment among women at high risk for breast cancer. Breast Cancer Res. Treat. 28: 145–155.
Lerman, C., Schwarz, M., Miller, S., Daly, M., Sands, C., and Rimer, B. (1996). A randomized trial of breast cancer risk counseling interacting effects of counseling, educational level, and coping style. Health Psychol. 15: 75–83.
Leventhal, H., Leventhal, E. A., and Cameron, L. (2001). Representations, procedures, and affect in illness self-regulation: A perceptual-cognitive model. In Baum A., and Revenson, T. (Eds.), Handbook of Health Psychology, Erlbaum, Mahwah, NJ.
Lipkus, I., Kuchibhatla, M., McBride, C., Bosworth, H., Pollak, K., Siegler, I., and Rimer, B. (2000). Relationships among breast cancer perceived absolute risk, comparative risk, and worries. Cancer Epidemiol. Biomarkers Prev. 9: 973–975.
Lloyd, S., Watson, M., Waites, B., Meyer, L., Eeles, R., Ebbs, S., and Tylee, A. (1996). Familial breast cancer: A controlled study of risk perception, psychological morbidity and health beliefs in women attending for genetic counseling. Br. J. Cancer 74: 482–487.
Loescher, L. (2003). Cancer worry in women with hereditary risk factors for breast cancer. Oncol. Nurs. Forum 30: 767–772.
MacCallum, R., Roxnowski, M., and Necowitz, L. (1992). Model modifications in covariance structure analysis: The problem of capitalization on chance. Psychol. Bull. 111: 490–504.
Martin, J., Smith, B., Matthews, M., and Ventura, S. (1999). Births and deaths: Preliminary data for (1998). Natl. Vital Stat. Rep. 47: 25, 1–45.
McCaul, K., Branstetter, A., Schroeder, D., and Glasgow, R. (1996a). What is the relationship between breast cancer risk and mammography screening? A meta-analytic review. Health Psychol. 15: 423–429.
McCaul, K., Schroeder, D., and Reid, P. (1996b). Breast cancer worry and screening: Some prospective data. Health Psychol. 15: 430–433.
McGregor B., Bowen D., Ankerst, D., Andersen, M., Yasui, Y., and McTiernan, A. (2004). Optimism, perceived risk of breast cancer and cancer worry among a community-based sample of women. Health Psychol. 23: 339–344.
Meiser, B., Butow, P., Barratt, A., Friedlander, M., Kirk, J., Gaff, C., Haan, E., Aittomaki, K., and Tucker, K. (2000a). Breast cancer screening uptake in women at increased risk of developing hereditary breast cancer. Breast Cancer Res. Treat. 59: 101–111.
Meiser, B., Tiller, K., Gleeson, M., Andrews, L., Robertson, G., and Tucker, K. (2000b). Psychological impact of prophylactic oophorectomy in women at increased risk for ovarian cancer. Psycho-Oncology 9: 496–503.
Montgomery, G., Erblich, J., DiLorenzo, T., and Bovbjerg, D. (2003). Family and friends with disease: their impact on perceived risk. Prev. Med. 37: 242–249.
Moran, M., Mazzocco, V., Fiscus, W., and Koza, E. (1989). Coronary heart disease risk assessment. Am. J. Prev. Med. 5: 330–336.
Mouchawar, J., Byers, T., Cutter, G., Dignan, M., and Michael, S. (1999). A study of the relationship between family history of breast cancer and knowledge of breast cancer genetic testing prerequisites. Cancer Detect. Prevent. 23: 22–30.
Neise, C., Rauchfuss, M., Paepke, S., Beier, K., and Lichtenegger, W. (2001). Risk perception and psychological strain in women with a family history of breast cancer. Onkilogie 24: 470–475.
Ransford, H., (1986). Race, heart disease worry and health protective behavior. Soc. Sci. Med. 22: 1335–1362.
Steiger, J., Shapiro, A., and Browne, M. (1985). On the multivariate asymptotic distribution of sequential Chi-Square statistics. Psychometrika 50: 253–264.
Stefanek, M., and Wilcox, P. (1991). First degree relatives of breast cancer patients: Screening practices and provision of risk information. Cancer Detect. Prevent. 15: 379–384.
Taylor, K., DiPlacido, J., Redd, W., Faccenda, K., Greer, L., and Perlmutter, A. (1999). Demographics, family histories, and psychological characteristics of prostate carcinoma screening participants. Cancer 85: 1305–1312.
Trask, T., Paterson, A., Wang, C., Hayasaks, S., Milliron, K., Blumberg, L., Gonzalex, R., Murray, S., and Merajver, S. (2001). Cancer-specific worry interference in women attending a breast and ovarian cancer risk evaluation program: Impact on emotional distress and health functioning. Psycho-Oncology 10: 349–360.
Van Dijk, S., Otten, W., Zoeteweij, M., Timmermans, D., van Asperen, C., and Breuning, M. (2003). Genetic counseling and the intention to undergo prophylactic mastectomy: Effects of a breast cancer risk assessment. Br. J. Cancer 88: 1675–1681.
Valdimarsdottir, H., Bovbjerg, D., Kash, K., Holland, J., Osborne, M., and Miller, D. (1995). Psychological distress in women with a familial risk of breast cancer. Psycho-Oncology 4: 133–141.
Vernon, S., Myers, R., Tilley, B., and Li, S. (2001). Factors associated with perceived risk in automotive employees at increased risk of colorectal cancer. Cancer Epidemiol. Biomarkers Prev. 10: 35–43.
Weinstein, N. (1987). Unrealistic optimism about susceptibility to health problems: Conclusions from a community-wide sample. J. Behav. Med. 10: 481–500.
Zakowski, S., Valdimarsdottir, H., Bovbjerg, D., Borgen, P., Holland, J., Kash, K., Holland, J., Osborne, M., and Miller, D. (1998). Predictors of intrusive thoughts and avoidance in women with family histories of breast cancer. Ann. Behav. Med. 19: 362–369.
ACKNOWLEDGMENT
This study was supported by the Yeshiva University Faculty Summer Fellowship, 2001.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DiLorenzo, T.A., Schnur, J., Montgomery, G.H. et al. A Model of Disease-Specific Worry in Heritable Disease: The Influence of Family History, Perceived Risk and Worry About Other Illnesses. J Behav Med 29, 37–49 (2006). https://doi.org/10.1007/s10865-005-9039-y
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10865-005-9039-y