Abstract
Purpose
To report on a woman who conceived naturally and had a normal intrauterine pregnancy following transplantation of frozen/thawed ovarian tissue but decided to have an early abortion due to recurrence of breast cancer.
Methods
The patient was diagnosed breast cancer and received antineoplastic treatment that forced her into premature ovarian insufficiency and infertility. Ovarian tissue cryopreserved prior to chemotherapy was transplanted following cancer treatment restoring fertility and regular menstrual cycles.
Results
The patient conceived 6 month after transplantation. However, she experienced recurrence of breast cancer and decided on legal termination of the pregnancy in the first trimester.
Discussion
The obtained pregnancy only 6 month following transplantation underlines the ability of the procedure. The recurrence occurred near the original site of the tumor and was most unlikely related to the transplantation. The activity of the transplanted tissue is likely to be destroyed by the renewed antineoplastic treatment she will receive. However, she still has the majority of one ovary cryostored and may later want to undergo additional transplantation to regain fertility or to have menstrual cycles back.
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References
Jemal A, Ward E, Thun M. Declining death rates reflect progress against cancer. PLoS One. 2010;5:e9584.
Lamar CA, Decherney AH. Fertility preservation: state of the science and future research directions. Fertil Steril. 2009;91:316–9.
Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Eng J Med. 2005;21:318–21.
Schmidt KT, Rosendahl M, Ernst E, et al. Autotransplantation of cryopreserved ovarian tissue in 12 women with chemotherapy-induced premature ovarian failure: the Danish experience. Fertil Steril. 2011;95:695–701.
Detti L, Daniel CM, Williams LJ. Applicability of adult techniques for ovarian preservation to childhood cancer patients. J Assist Reprod Genet. 2012;29:985–95.
Demeestere I, Simon P, Buxant F, Robin V, Fernandez SA, Centner J, et al. Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Hum Reprod. 2006;21:2010–4.
Yding Andersen C, Kristensen SG, Greve T, Tryde Schmidt K. Cryopreservation of ovarian tissue for fertility preservation in young female oncological patients. Future Oncol. 2012;8:595–608.
Andersen CY, Silber SJ, Berghold SH, Jorgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod Biomed Online. 2012;25:128–32.
Schmidt KT, Byskov AG, Nyeboe Andersen A, Müller J, Yding Andernsen C. Density and distribution of primordial follicles in single pieces of cortex from 21 patients and in individual pieces of cortex from three entire human ovaries. Hum Reprod. 2003;18:1158–64.
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Eng J Med. 2005;16:1659–72.
Acknowledgement
The financial support from the foundations of Civil Engineer Frode V. Nyegaard & wife, The Health Faculty at Aarhus University, the Danish Cancer Society (DP05112/ R2-A41-09-S2), The Danish Medical Research Council (271-07-0452; 09-072265), the Novo Nordic Foundation, Sophus Carl Emil Friis and wife Olga Doris Friis’ foundation, and the University Hospital of Copenhagen, is gratefully acknowledged.
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Capsule
A woman achieves pregnancy following autotransplantion of cryopreserved ovarian tissue but undergoes legal abortion due to cancer recurrence.
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Ernst, E.H., Offersen, B.V., Andersen, C.Y. et al. Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence. J Assist Reprod Genet 30, 975–978 (2013). https://doi.org/10.1007/s10815-013-0026-x
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DOI: https://doi.org/10.1007/s10815-013-0026-x