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Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification

  • ASSISTED REPRODUCTION TECHNOLOGIES
  • Published:
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Abstract

Purpose

To compare the efficacy of single vitrified-warmed blastocyst embryo transfer (SVBT) versus double vitrified-warmed blastocyst embryo transfer (DVBT) according to the day of vitrification.

Methods

This retrospective study included a total of 1,051 cycles in women less than 37 years of age with their autologous SVBT cryopreserved on day 5 (5d-SVBT, n = 737) or day 6 (6d-SVBT, n = 154) and DVBT on day 5 (5d-DVBT, n = 129) or day 6 (6d-DVBT, n = 31) from January 2009 to December 2011.

Results

The clinical pregnancy rate (41.8 % vs. 48.1 %, p = 0.184) and ongoing pregnancy rate (36.6 % vs. 45.0 %, p = 0.072) were not significantly different between the 5d-SVBT group and the 5d-DVBT group. However, the clinical pregnancy (29.9 % vs. 58.1 %, p = 0.003) and ongoing pregnancy rates (23.4 % vs. 51.6 %, p = 0.001) were significantly lower in the 6d-SVBT group compared with those in the 6d-DVBT group. The implantation rate (42.2 % vs. 34.5 %, p = 0.03) of the 5d-SVBT group was significantly higher than that of the 5d-DVBT group, while the implantation rate (29.9 % vs. 37.1 %, p = 0.303) of the 6d-SVBT group was not statistically different compared with that in the 6d-DVBT group. The multiple pregnancy rates (1.0 % in the 5d-SVBT group vs. 38.7 % in the 5d-DVBT group, p < 0.001 and 0 % in the 6d-SVBT group vs. 22.2 % in the 6d-DVBT group, p = 0.001) were statistically significantly lower in the SVBT group compared with those in the DVBT group regardless of the day of vitrification.

Conclusions

This study showed that the 5d-SVBT resulted in comparable clinical outcomes compared to the 5d-DVBT while the 6d-SVBT yielded significantly lower clinical outcomes compared to the 6d-DVBT.

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Conflicts of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Maria Fertility Clinic, 9th floor, Samsung Fire Bldg. 2-1 Beomeo 3-Dong, Suseong-Gu, Daegu, 706-743, Republic of Korea

    Sang Min Kang, Sang Won Lee, Joo Cheol Kim & Seong Goo Lee

  2. Seoul Maria Fertility Hospital, 103-11 Shinseol-Dong, Dongdaemun-Gu, Seoul, 130-812, Republic of Korea

    San Hyun Yoon & Jin Ho Lim

Authors
  1. Sang Min Kang
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  2. Sang Won Lee
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  3. San Hyun Yoon
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  4. Joo Cheol Kim
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  5. Jin Ho Lim
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  6. Seong Goo Lee
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Corresponding author

Correspondence to Seong Goo Lee.

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Capsule

Transferring single vitrified-warmed blastocyst developed on day 5 could result in acceptable pregnancy rates while reducing the risk of multiple pregnancies.

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Kang, S.M., Lee, S.W., Yoon, S.H. et al. Comparison of clinical outcomes between single and double vitrified-warmed blastocyst embryo transfer according to the day of vitrification. J Assist Reprod Genet 30, 779–785 (2013). https://doi.org/10.1007/s10815-013-0017-y

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  • DOI: https://doi.org/10.1007/s10815-013-0017-y

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