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The liver: another organ involved in Muir Torre syndrome?

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Abstract

Muir Torre syndrome is a rare autosomal dominant cancer-predisposing syndrome characterized by the occurrence of sebaceous gland neoplasms and/or keratoacanthomas associated with visceral malignancies that belong to the spectrum of hereditary non polyposis colorectal cancer (HNPCC), i.e., tumors of gastrointestinal and genitourinary tracts. Hepatobiliary malignancy in association with Muir Torre syndrome has rarely been reported. Here, we describe a case of Muir Torre syndrome associated with an hepatocellular-carcinoma in a patient with a non-cirrhotic liver and an HNPCC-family with multiple cases of hepatocellular carcinoma.

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Abbreviations

MTS:

Muir-Torre syndrome

HNPCC:

Hereditary non polyposis colorectal cancer

HCC:

Hepatocellular carcinoma

FNAB:

Fine needle aspiration biopsy

HOMA:

Homeostasis model assessment

NAFLD:

Non alcoholic fatty liver disease

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy

    F. Morando, A. Romano, M. Cavallin, S. Piano, A. Gatta & P. Angeli

  2. Unit of Dermatology, University of Padova, Padova, Italy

    M. Alaibac

  3. Department of Diagnostic Medical Sciences and Special Therapies, Pathology Unit, University of Padova, Padova, Italy

    M. Pizzi & C. Mescoli

  4. Department of Oncological and Surgical Sciences, University of Padova, Padova, Italy

    P. Pilati

Authors
  1. F. Morando
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  2. M. Alaibac
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  3. A. Romano
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  4. M. Cavallin
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  5. S. Piano
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  6. M. Pizzi
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  7. C. Mescoli
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  8. P. Pilati
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  9. A. Gatta
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  10. P. Angeli
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Correspondence to P. Angeli.

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Morando, F., Alaibac, M., Romano, A. et al. The liver: another organ involved in Muir Torre syndrome?. Familial Cancer 11, 7–12 (2012). https://doi.org/10.1007/s10689-011-9450-1

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  • DOI: https://doi.org/10.1007/s10689-011-9450-1

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