Abstract
Aim Quantitative MRI assessments of cardiac structure and function are possible and potentially useful for longitudinal clinical monitoring. The aim of this study was to compare the magnitude and repeatability of left ventricular (LV) ejection fraction (EF) and mass (LVM) measurements in patients with clinically distinct cardiac conditions. Materials and Methods Patients were recruited into four groups: (i) congestive heart failure (CHF), (ii) left ventricular hypertrophy (LVH), (iii) recent post myocardial infarct (PMI), and (iv) healthy normal volunteers (HNV). LV short-axis images were acquired on a 1.5T MRI scanner and analysed on a satellite workstation. EF and LVM (at ED) values were derived from myocardial segmentations, and intra-observer test-retest coefficients of repeatability (CoR) were determined for each cohort. Results The mean EF for the CHF patients (30.3%) was lower than for the other cohorts (LVH 72.7%, PMI 53.0%, HNV 67.0%; P < 0.0002). As expected, the mean LVM for the CHF patients (143 g) was greater than for the other cohorts (LVH 122 g, PMI 124 g, HNV 107 g), but only significant when compared to the HNV cohort (P = 0.004). The intra-observer CoR values for EF were 1.5% (LVH), 1.6% (HNV), 2.6% (PMI) and 5.5% (CHF), and 4.6 g (HNV), 6.7 g (PMI), 8.3 g (CHF) and 9.8 g (LVH) for LVM. Conclusion The EF, LVM and associated repeatability parameters are variable and dependent upon the clinical condition under investigation. It is important that reproducibility data for EF and LVM are acquired individually and specifically on a per-cohort basis if the parameters are to form reliable endpoints for longitudinal clinical follow-up assessments.
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Abbreviations
- CHF:
-
Congestive heart failure
- CoR:
-
Coefficient of repeatability
- CoV:
-
Coefficient of variation
- ED:
-
End diastole
- EF:
-
Ejection fraction
- ES:
-
End systole
- HNV:
-
Healthy normal volunteers
- LV:
-
Left ventricle
- LVH:
-
Left ventricular hypertrophy
- LVM (ED) :
-
Left ventricular mass at end diastole
- MRI:
-
MRI
- PMI:
-
Post myocardial infarct
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Acknowledgments
Prof Allan Struthers, Dr Helen Simpson, and Miss Wendy Urquhart, Division of Medicine and Therapeutics, University of Dundee School of Medicine, Ninewells Hospital, Dundee DD1 9SY, UK. Mrs Lynsay Allan, Mrs Elena Crowe, Mrs Baljit Jagpal, Mrs Trudy McLeay, Mrs Wendy Milne, and Mrs Norma Gourlay, Department of Clinical Radiology, NHS Tayside, Ninewells Hospital, Dundee DD1 9SY, UK.
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Gandy, S.J., Waugh, S.A., Nicholas, R.S. et al. MRI comparison of quantitative left ventricular structure, function and measurement reproducibility in patient cohorts with a range of clinically distinct cardiac conditions. Int J Cardiovasc Imaging 24, 627–632 (2008). https://doi.org/10.1007/s10554-008-9293-5
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DOI: https://doi.org/10.1007/s10554-008-9293-5