Skip to main content

Advertisement

SpringerLink
Log in

Commentary: Serum lycopene and prostate cancer progression: a re-consideration of findings from the prostate cancer prevention trial

  • Brief report
  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

A recent analysis in the Prostate Cancer Prevention Trial (PCPT) appeared to show no association between serum lycopene and prostate cancer risk, but the unique study design of the PCPT and the complexity of prostate cancer epidemiology suggest an alternative interpretation of the reported findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Kristal AR, Till C, Platz EA et al (2011) Serum lycopene concentration and prostate cancer risk: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev 20:638–646

    Article  PubMed  CAS  Google Scholar 

  2. Sakr WA, Grignon DJ, Crissman JD et al (1994) High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo 8:439–443

    PubMed  CAS  Google Scholar 

  3. Thompson IM, Goodman PJ, Tangen CM et al (2003) The influence of finasteride on the development of prostate cancer. N Engl J Med 349:215–224

    Article  PubMed  CAS  Google Scholar 

  4. Stark JR, Perner S, Stampfer MJ et al (2009) Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3? J Clin Oncol 27:3459–3464

    Article  PubMed  Google Scholar 

  5. Andren O, Fall K, Franzen L, Andersson SO, Johansson JE, Rubin MA (2006) How well does the Gleason score predict prostate cancer death? a 20-year followup of a population based cohort in Sweden. J Urol 175:1337–1340

    Article  PubMed  Google Scholar 

  6. Mucci LA, Powolny A, Giovannucci E et al (2009) Prospective study of prostate tumor angiogenesis and cancer-specific mortality in the health professionals follow-up study. J Clin Oncol 27:5627–5633

    Article  PubMed  Google Scholar 

  7. Krishnan AV, Feldman D (2010) Molecular pathways mediating the anti-inflammatory effects of calcitriol: implications for prostate cancer chemoprevention and treatment. Endocr Relat Cancer 17:R19–R38

    Article  PubMed  CAS  Google Scholar 

  8. Krishnan AV, Feldman D (2011) Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol 51:311–336

    Article  PubMed  CAS  Google Scholar 

  9. Yang CM, Yen YT, Huang CS, Hu ML (2011) Growth inhibitory efficacy of lycopene and β-carotene against androgen-independent prostate tumor cells xenografted in nude mice. Mol Nutr Food Res 55:606–612

    Article  PubMed  CAS  Google Scholar 

  10. Cervi D, Pak B, Venier NA et al (2010) Micronutrients attenuate progression of prostate cancer by elevating the endogenous inhibitor of angiogenesis, platelet factor-4. BMC Cancer 10:258

    Article  PubMed  Google Scholar 

  11. Kirsh VA, Mayne ST, Peters U et al (2006) A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 15:92–98

    Article  PubMed  CAS  Google Scholar 

  12. Peters U, Leitzmann MF, Chatterjee N et al (2007) Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 16:962–968

    Article  PubMed  CAS  Google Scholar 

  13. Stram DO, Hankin JH, Wilkens LR et al (2006) Prostate cancer incidence and intake of fruits, vegetables and related micronutrients: the multiethnic cohort study (United States). Cancer Causes Control 19:1193–1207

    Article  Google Scholar 

  14. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC (1995) Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87:1767–1776

    Article  PubMed  CAS  Google Scholar 

  15. Hsing AW, Comstock GW, Abbey H, Polk BF (1990) Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. J Natl Cancer Inst 82:941–946

    Article  PubMed  CAS  Google Scholar 

  16. Gann PH, Ma J, Giovannucci E et al (1999) Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 59:1225–1230

    PubMed  CAS  Google Scholar 

  17. Tzonou A, Signorello LB, Lagiou P, Wuu J, Trichopoulos D, Trichopoulou A (1999) Diet and cancer of the prostate: a case-control study in Greece. Int J Cancer 80:704–708

    Article  PubMed  CAS  Google Scholar 

  18. Mills PK, Beeson WL, Phillips RL, Fraser GE (1989) Cohort study of diet, lifestyle, and prostate cancer in adventist men. Cancer 64:598–604

    Article  PubMed  CAS  Google Scholar 

  19. Vogt TM, Mayne ST, Graubard BI et al (2002) Serum lycopene, other serum carotenoids, and risk of prostate cancer in US blacks and whites. Am J Epidemiol 155:1023–1032

    Article  PubMed  CAS  Google Scholar 

  20. Key TJ, Appleby PN, Allen NE et al (2007) Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European prospective investigation into cancer and nutrition study. Am J Clin Nutr 86:672–681

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, MA, Boston, 02136, USA

    Edward Giovannucci

  2. Department of Medicine, Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, USA

    Edward Giovannucci

Authors
  1. Edward Giovannucci
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Edward Giovannucci.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Giovannucci, E. Commentary: Serum lycopene and prostate cancer progression: a re-consideration of findings from the prostate cancer prevention trial. Cancer Causes Control 22, 1055–1059 (2011). https://doi.org/10.1007/s10552-011-9776-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-011-9776-x

Keywords

Search

Navigation