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The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer

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Abstract

The 70-gene signature (MammaPrint™) is a prognostic tool used to guide adjuvant treatment decisions. The aim of this study was to assess its value to predict chemosensitivity in the neoadjuvant setting. We obtained the 70-gene profile of stage II–III patients prior to neoadjuvant chemotherapy and classified the prognosis-signatures. Pathological complete remission (pCR) was used to measure chemosensitivity. Among 167 patients, 144 (86%) were having a poor and 23 (14%) a good prognosis-signature. None of the good prognosis-signature patients achieved a pCR (0/23), whereas 29/144 patients (20%) in the poor prognosis-signature group did (P = 0.015). All triple-negative tumors (n = 38) had a poor prognosis-signature. Within the non triple-negative subgroup, the response of the primary tumor remained associated with the classification of the prognosis-signature (P = 0.023). A pCR is unlikely to be achieved in tumors that have a good prognosis-signature. Tumors with a poor prognosis-signature are more sensitive to chemotherapy.

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Conflicts of interest

This study was financially supported by Agendia, the commercial company that markets the 70-gene signature as Mammaprint. L. van ‘t Veer is a shareholder in and (part time) employed by Agendia. A.M. Glas is employed by Agendia.

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Authors and Affiliations

  1. Department of Surgical Oncology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Marieke E. Straver, Emiel J. Th. Rutgers & Marie-Jeanne T. F. D. Vrancken Peeters

  2. Agendia BV, Sience Park 406, 1098 XH, Amsterdam, The Netherlands

    Annuska M. Glas & Laura J. van‘t Veer

  3. Department of Pathology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Juliane Hannemann, Jelle Wesseling, Marc J. van de Vijver & Laura J. van‘t Veer

  4. Department of Biometrics, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Harm van Tinteren

  5. Department of Medical Oncology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Sjoerd Rodenhuis

Authors
  1. Marieke E. Straver
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  2. Annuska M. Glas
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  5. Marc J. van de Vijver
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  9. Laura J. van‘t Veer
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  10. Sjoerd Rodenhuis
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Correspondence to Sjoerd Rodenhuis.

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Straver, M.E., Glas, A.M., Hannemann, J. et al. The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat 119, 551–558 (2010). https://doi.org/10.1007/s10549-009-0333-1

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  • DOI: https://doi.org/10.1007/s10549-009-0333-1

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