Abstract
We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor–liquid–solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 μm in wall thickness; 20 μm in height; and either 2.5 μm, 4.1 μm, 4.6 μm, or 6.4 μm in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 μm inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices.
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V.W.S. Chan, S. Nazarnia, Z. Kaszas, A. Perlas, Anesth. Analg. 89, 1006 (1999). doi:10.1097/00000539-199910000-00034
C. Chen, J.G. Santiago, J. Microelectromech. Syst. 11, 672 (2002). doi:10.1109/JMEMS.2002.805055
J. Chen, K.D. Wise, J.F. Hetke, S.C. Bledsoe, IEEE Trans. Biomed. Eng. 44, 760 (1997). doi:10.1109/10.605435
L. Chen, J. Ma, F. Tan, Y. Guan, Sens. Actuators B Chem. 88, 260 (2003). doi:10.1016/S0925-4005(02)00348-9
Y. Choi, M.A. McClain, M.C. LaPlaca, A. Bruno Frazier, M.G. Allen, Biomed. Microdevices 9, 7 (2007). doi:10.1007/s10544-006-9004-8
H. Cui, Z. Silber-Li, S. Zhu, Phys. Fluids 16, 1803 (2004). doi:10.1063/1.1691457
J. Edmonds-Seal, G.M.C. Paterson, A.B. Loach, J. R. Soc. Med. 73, 111 (1980)
R. Freedman, B.J. Hoffer, D.J. Woodward, Br. J. Pharmacol. 54, 529 (1975)
T. Kawano, Y. Kato, R. Tani, H. Takao, K. Sawada, M. Ishida, IEEE Trans. Elctron Devices 51, 415 (2004). doi:10.1109/TED.2003.822473
M. Legault, P.P. Rompre, R.A. Wise, J. Neurosci. 15, 1635 (2000)
L. Li, V. Rema, F.F. Ebner, J. Neurophysiol. 94, 3342 (2005). doi:10.1152/jn.00357.2005
L. Lin, A.P. Pisano, J. Microelectromech. Syst. 8, 78 (1999). doi:10.1109/84.749406
D.V. McAllister, M.G. Allen, M.R. Prausnitz, Annu. Rev. Biomed. Eng. 02, 289 (2000). doi:10.1146/annurev.bioeng.2.1.289
A. Paavola, J. Yliruusi, Y. Kajimoto, E. Kalso, T. Wahlstrom, P. Rosenberg, Pharm. Res. 12, 1997 (1995). doi:10.1023/A:1016264527738
D.P. Papageorgiou, S.E. Shore, S.C. Bledsoe Jr., K.D. Wise, J. Microelectromech. Syst. 15, 1025 (2006). doi:10.1109/JMEMS.2005.863733
M.R. Prausnitz, Adv. Drug Deliv. Rev. 56, 581 (2004). doi:10.1016/j.addr.2003.10.023
S. Rajaraman, S. Choi, R.H. Shafer, J.D. Ross, J. Vukasinovic, Y. Choi, S.P. DeWeerth, A. Glezer, M.G. Allen, J. Micromech. Microeng. 17, 163 (2007). doi:10.1088/0960-1317/17/1/021
M. Richter, P. Woias, D. Weib, Sens. Actuators A Phys. 62, 480 (1997). doi:10.1016/S0924-4247(97)01486-6
J. Rodriguez, V. Rodriguez, A. Naveira, O. Quintela, M. Barcena, E. Gallardo, F. Gude, J. Alvarez, Acta Anaesthesiol. Scand. 45, 893 (2001). doi:10.1034/j.1399-6576.2001.045007893.x
N. Roxhed, P. Griss, G. Stemme, Biomed. Microdevices 10, 271 (2008). doi:10.1007/s10544-007-9133-8
K. Takei, T. Kawashima, K. Sawada, M. Ishida, IEEE Sens. J. 8, 470 (2008a). doi:10.1109/JSEN.2008.918262
K. Takei, T. Kawashima, T. Kawano, H. Takao, K. Sawada, M. Ishida, J Micromechanics Microengineering, 18, 035033 (2008b). doi:10.1088/0960-1317/18/3/035033
S. Takeuchi, D. Ziegler, Y. Yoshida, K. Mabuchi, T. Suzuki, Lab Chip 5, 519 (2005). doi:10.1039/b417497f
K. Takoh, T. Ishibashi, T. Matsue, M. Nishizawa, Sens. Actuators B Chem. 108, 683 (2005). doi:10.1016/j.snb.2004.12.090
B. Todd Sitzman, C.A. DiFazio, P.A. Playfair, R.A. Stevens, C.F. Hanes, T.B. Herman, H. Kendall Yates, G.S. Leisure, Reg. Anesth. Pain Med. 26, 246 (2001). doi:10.1053/rapm.2001.22587
R.S. Wagner, W.C. Ellis, Appl. Phys. Lett. 4, 89 (1964). doi:10.1063/1.1753975
A.P. Wolff, O.H.G. Wilder Smith, B.J.P. Crul, M.P. van de Heijden, J. Groen, Anesth. Analg. 99, 496 (2004). doi:10.1213/01.ANE.0000122268.70154.A9
C. Ziegler, T. Suzuki, S. Takeuchi, J. Microelectromech. Syst. 15, 1477 (2006). doi:10.1109/JMEMS.2006.879681
Acknowledgements
The authors would like to thank Mr. Mitsuaki Ashiki for his assistance with fabrication processes. This work was supported by a Grant-in-Aid for Scientific Research (S)(MI) and for JSPS Fellows (KT), by the global COE Program “Frontiers of Intelligent Sensing” from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MI), and by grants from the National Institute of Advanced Industrial Science and Technology (HK).
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Takei, K., Kawashima, T., Kawano, T. et al. Out-of-plane microtube arrays for drug delivery—liquid flow properties and an application to the nerve block test. Biomed Microdevices 11, 539–545 (2009). https://doi.org/10.1007/s10544-008-9259-3
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DOI: https://doi.org/10.1007/s10544-008-9259-3