Skip to main content
SpringerLink
Log in

Pancreatic Islet Cell Transplantation: An Update

  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

Transplantation of pancreatic islets, as a therapeutic modality for type 1 diabetes mellitus (T1DM), at this stage of its development, is reserved for patients with severe glycemic variability, progressive diabetic complications, and life threatening hypoglycemia unawareness, regardless of intensive insulin management. It has not succeeded to become the method of choice for treating T1DM because of limited supply and suboptimal yields of procurement and isolation of islets, graft failure, and relatively high requirements, i.e., at least 10,000 functional Islet Equivalents per kg of patient weight, to achieve prolonged insulin independence and glucose stability. Efforts aimed at making islet transplantation a competitive alternative to exogenous insulin injections for treating T1DM have focused on improving the longevity and functionality of islet cells. In order to succeed, these efforts need to be complemented by others to optimize the rate and efficiency of encapsulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5

Similar content being viewed by others

References

  1. Blyth, M. G., and C. Pozrikidis. Particle encapsulation due to thread breakup in stokes flow. J. Fluid Mech. 617:141–166, 2008.

    Article  Google Scholar 

  2. Cohen, I., H. Li, J. L. Hougland, et al. Using selective withdrawal to coat microparticles. Science 292:265–267, 2001.

    Article  PubMed  CAS  Google Scholar 

  3. Cruise, G. M., O. D. Hegre, D. S. Scharp, and J. A. Hubbell. A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets. Biotechnol. Bioeng. 57:655–665, 1998.

    Article  PubMed  CAS  Google Scholar 

  4. de Vos, P., B. J. de Haan, J. A. Kamps, et al. ζ-Potentials of alginate-PLL capsules: a predictive measure for biocompatibility? J. Biomed. Mater. Res. A 80:813–819, 2007.

    PubMed  Google Scholar 

  5. Golocheikine, A., V. Tiriveedhi, N. Angaswamy, et al. Cooperative signaling for angiogenesis and nonvascularization by VEGF and HGF following islet transplantation. Transplantation 90:1366–1373, 2010.

    Article  Google Scholar 

  6. Hatziavramidis, D., and C. Pozrikidis. Hydrodynamic analysis of pancreatic islet micro-encapsulation by selective withdrawal. Eng. Anal. Bound. Elem. 32:11–20, 2008.

    Article  Google Scholar 

  7. Hu, H. H., D. D. Joseph, and M. J. Crochet. Direct simulation of fluid particle motions. Theor. Comput. Fluid Dyn. 3:285–306, 1992.

    Article  CAS  Google Scholar 

  8. Kizilel, S., V. H. Perez-Luna, and F. Teymour. Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces. Langmuir 20:8652–8658, 2004.

    Article  PubMed  CAS  Google Scholar 

  9. Kroon, E., L. A. Martinson, K. Kadoya, et al. Pancreatic endotherm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat. Biotechnol. 26:443–452, 2008.

    Article  PubMed  CAS  Google Scholar 

  10. Lakey, J. R., T. Kin, G. L. Warnock, et al. Long-term graft function after allogeneic islet transplantation. Cell Transplant. 16:441–446, 2007.

    PubMed  Google Scholar 

  11. Lee, G. B., C. I. Hung, B. J. Ke, et al. Hydrodynamic focusing for a micromachined flow cytometer. J. Fluid Eng. Trans. ASME 123:672–679, 2001.

    Article  Google Scholar 

  12. Lister, J. R. Selective withdrawal from viscous two-layer system. J. Fluid Mech. 198:231–254, 1989.

    Article  Google Scholar 

  13. McCall, M., C. Toso, J. Emamaullee, et al. The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice. Surgery 150:48–55, 2011.

    Article  PubMed  Google Scholar 

  14. Miao, G., J. Mace, M. Kirby, et al. In vitro and in vivo improvement of islet survival following treatment with nerve growth factor. Transplantation 81:519–524, 2006.

    Article  PubMed  CAS  Google Scholar 

  15. O’Sullivan, E. S., A. Vegas, D. G. Anderson, and G. C. Weir. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocrine Rev. 32:827–844, 2011.

    Article  Google Scholar 

  16. Olsson, A., G. Stemme, and E. Stemme. Diffuser-element design investigation for valve-less pumps. Sensors Actuators A 57:137–143, 1996.

    Article  Google Scholar 

  17. Pan, L. S., T. Y. Ng, G. R. Liu, et al. Analytical solutions for the dynamic analysis of a valveless micropump. Sensors Actuators A 93:173–181, 2001.

    Article  Google Scholar 

  18. Pileggi, A., R. D. Molano, T. Berney, et al. Heme Oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 50:1983–1991, 2001.

    Article  PubMed  CAS  Google Scholar 

  19. Plesner, A. and C. B. Verchere. Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation. J. Transplant. 2011: article ID 979527. doi:10.1155/2011/979527.

  20. Plesner, A., G. Soukhatcheva, R. G. Korneluk, and C. B. Verchere. XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model. Islets 2:1–6, 2010.

    Article  Google Scholar 

  21. Rivas-Carrillo, J. D., A. Soto-Gutierez, N. Navarro-Alvarez, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes 56:1259–1267, 2007.

    Article  PubMed  CAS  Google Scholar 

  22. Robertson, R. P. Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 59:1285–1291, 2010.

    Article  PubMed  CAS  Google Scholar 

  23. Ryan, E. A., J. R. T. Lakey, B. W. Paty, et al. Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 51:2148–2157, 2002.

    Article  PubMed  CAS  Google Scholar 

  24. Schneider, S., P. Feilen, V. Sloty, et al. Multilayer capsules: a promising microencapsulation system for transplantation of pancreatic islets. Biomaterials 22:1961–1970, 2001.

    Article  PubMed  CAS  Google Scholar 

  25. Scott, W. E., B. P. Weegman, J. Ferrer-Fabrega, et al. Pancreas oxygen persufflation increases ATP levels as shown by nuclear magnetic resonance. Transplant. Proc. 42:2011–2015, 2010.

    Article  PubMed  CAS  Google Scholar 

  26. Shapiro, A. M. J., J. R. T. Lakey, E. A. Ryan, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343:230–238, 2000.

    Article  PubMed  CAS  Google Scholar 

  27. Shapiro, A. M. J., C. Ricordi, B. J. Hering, et al. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355:1318–1330, 2006.

    Article  PubMed  CAS  Google Scholar 

  28. Sharp, D., P. Lacy, C. Ricordi, et al. Human islet transplantation in patients with type I diabetes. Transplant. Proc. 21:2744–2745, 1989.

    Google Scholar 

  29. Tateishi, K., J. He, O. Taranova, et al. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J. Biol. Chem. 283:31601–31607, 2008.

    Article  PubMed  CAS  Google Scholar 

  30. Uonaga, T., K. Toyoda, T. Okitsu, et al. FGF-21 enhances islet engraftment in mouse syngeneic islet transplantation model. Islets 2:247–251, 2010.

    Article  PubMed  Google Scholar 

  31. Wyman, J. L., S. Kizilel, R. Skarbek, et al. Immunoisolating pancreatic islets by encapsulation with selective withdrawal. Small 3:683–690, 2007.

    Article  PubMed  CAS  Google Scholar 

  32. Yamahata, C., C. Vandevyver, F. Lacharme, et al. Pumping of mammalian cells with a nozzle-diffuser micropump. Lab Chip 5:1083–1088, 2005.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Chemical Engineering, National Technical University of Athens, Athens, 15780, Greece

    Dimitrios T. Hatziavramidis

  2. 2nd Department of Propaedeutic Surgery, School of Medicine, University of Athens, Athens, 11527, Greece

    Theodore M. Karatzas

  3. 1st Pediatric Clinic, School of Medicine, University of Athens, Athens, 11527, Greece

    George P. Chrousos

Authors
  1. Dimitrios T. Hatziavramidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Theodore M. Karatzas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. George P. Chrousos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dimitrios T. Hatziavramidis.

Additional information

Associate Editor Stefan Jockenhoevel oversaw the review of this article.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hatziavramidis, D.T., Karatzas, T.M. & Chrousos, G.P. Pancreatic Islet Cell Transplantation: An Update. Ann Biomed Eng 41, 469–476 (2013). https://doi.org/10.1007/s10439-012-0676-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10439-012-0676-3

Keywords

Search

Navigation