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Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

An Erratum to this article was published on 20 August 2013

Abstract

Purpose

To determine whether there is a significant association between human immunodeficiency virus (HIV)-related retinal microangiopathy and systemic cytomegalovirus (CMV) disease in HIV-infected patients.

Methods

Participants in this single-center, cross-sectional, retrospective study were 383 HIV-infected patients assessed for ocular manifestations before the beginning of antiretroviral therapy. The presence of HIV-related retinal microangiopathy, the presence of systemic CMV disease, laboratory data, and demographic information were determined by referring to medical records. The significance of any association between HIV-related retinal microangiopathy and systemic CMV disease was determined by use of the Chi-squared test and by multivariate analysis.

Results

HIV-related retinal microangiopathy was present in 85 patients, and was significantly associated with systemic CMV disease both by use of the Chi-squared test (P = 0.006) and by multivariate analysis (P = 0.045, odds ratio 2.03, 95 % confidence interval 1.02–4.06 adjusted for CD4+ cell count and plasma HIV-RNA level).

Conclusions

These findings indicate that microangiopathy may be involved in the development of CMV disease in HIV-infected patients. Thus, detection of the presence of HIV-related retinal microangiopathy is important in the management of HIV-infected patients.

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Acknowledgments

We thank Drs. Akifumi Imamura, Akihiko Suganuma, and Naoki Yanagisawa for proofreading and data management.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Metropolitan Komagome Hospital, 18-22, Honkomagome 3chome, Bunkyo, Tokyo, 113-0021, Japan

    Yuko Iwasaki, Narumichi Yamamoto, Tatsushi Kawaguchi, Noriko Ozaki & Kimio Murakami

  2. Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Bunkyo, Japan

    Atsushi Ajisawa

  3. Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Bunkyo, Japan

    Yuko Iwasaki, Tatsushi Kawaguchi & Manabu Mochizuki

  4. Clinical Research Center, Tokyo Medical and Dental University, Bunkyo, Japan

    Makoto Tomita

Authors
  1. Yuko Iwasaki
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  2. Narumichi Yamamoto
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  3. Tatsushi Kawaguchi
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Correspondence to Yuko Iwasaki.

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Iwasaki, Y., Yamamoto, N., Kawaguchi, T. et al. Human immunodeficiency virus-related retinal microangiopathy and systemic cytomegalovirus disease association . Jpn J Ophthalmol 57, 372–378 (2013). https://doi.org/10.1007/s10384-013-0247-7

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  • DOI: https://doi.org/10.1007/s10384-013-0247-7

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