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Improved short tau inversion recovery (iSTIR) for increased tumor conspicuity in the abdomen

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Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

Object

To develop an improved short tau inversion recovery (iSTIR) technique with simultaneous suppression of fat, blood vessels and fluid to increase tumor conspicuity in the abdomen for cancer screening.

Materials and methods

An adiabatic spectrally selective inversion pulse was used for fat suppression to overcome the reduced signal to noise ratio associated with chemically non-selective inversion pulse of STIR. A motion-sensitizing driven equilibrium was used for blood vessel suppression and a dual-echo single-shot fast spin echo acquisition was used for fluid suppression. The technique was optimized on four normal subjects and later tested on five patients referred for metastatic tumor evaluation.

Results

A velocity encoding of 2 cm/s achieved effective blood suppression even in small vessels. Subtraction of two images (one with 60 ms and the other with 280 ms echo time) acquired in the same echo train achieved excellent fluid suppression (>70 % reduction). Simultaneous suppression of fat, blood vessels and fluid improved the tumor conspicuity compared to corresponding fat-suppressed (STIR) image.

Conclusion

This technique generated two complementary images from a single scan: one that is equivalent to a STIR image and the other that qualitatively resembles a diffusion-weighted image and may have potential for magnetic resonance imaging cancer screening.

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Acknowledgments

The authors would like to thank Shelby Cuffley, B.S. and Meaghan Fox, B.S. for their help with the patient studies.

Author information

Author notes

  1. Aya Yassin

    Present address: Department of Radiology, Ain Shams University, Cairo, Egypt

Authors and Affiliations

  1. Applied Science Lab, GE Healthcare, Boston, MA, USA

    Ananth J. Madhuranthakam

  2. Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Karen S. Lee, Aya Yassin, Ivan Pedrosa, Neil M. Rofsky & David C. Alsop

  3. Applied Science Lab, GE Healthcare, Madison, WI, USA

    Jean H. Brittain

  4. Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9061, USA

    Ananth J. Madhuranthakam, Ivan Pedrosa & Neil M. Rofsky

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  1. Ananth J. Madhuranthakam
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Correspondence to Ananth J. Madhuranthakam.

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Madhuranthakam, A.J., Lee, K.S., Yassin, A. et al. Improved short tau inversion recovery (iSTIR) for increased tumor conspicuity in the abdomen. Magn Reson Mater Phy 27, 245–255 (2014). https://doi.org/10.1007/s10334-013-0410-7

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  • DOI: https://doi.org/10.1007/s10334-013-0410-7

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