Abstract
Autoimmune disorders encompass a wide spectrum of diseases that progress with several clinical findings. They can be organ-specific (such as Hashimoto’s thyroiditis) or they can involve multiple organs (such as SLE). The common characteristic of all these disorders is the production of different autoantibodies against various autoantigens along with inflammation. IgA nephropathy is the most common non-lupus glomerulopathy. It rarely coexists with SLE and has never been reported to coexist with Hashimoto’s thyroiditis. In this case report, a female patient diagnosed with SLE and Hashimoto’s thyroiditis and whose renal biopsy revealed IgA nephropathy is presented.
Similar content being viewed by others
References
Inman RD, Day NK. Immunologic and clinical aspects of immune complex disease. Am J Med. 1981;70:1097–106.
Biro E, Szekanecz Z, Danko K. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol. 2006;25:240–5.
Scofield RH. Autoimmune thyroid disease in systemic lupus erythematosus and Sjogren’s syndrome. Clin Exp Rheumatol. 1996;14:321–30.
D’Amico G. Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis. 2000;36:227–37.
Geddes CC, Rauta V, Gronhagen-Riska C, et al. A tricontinental view of IgA nephropathy. Nephrol Dial Transplant. 2003;18:1541–8.
Churg J, Bernstein J, Glassock RJ. Lupus nephritis. In: Churg J, Bernstein J, Glassock RJ, editors. Renal disease: classification and atlas of glomerular disease. 2nd ed. Tokyo: Igaku-Shoin; 1995. p. 151–5.
Weening JJ, D’Agati VD, Schwartz MM, et al. Classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol. 2004;15:241–50.
Austin HA, Muenz LR, Joyce KM, et al. Prognostic factors in lupus nephritis: contribution of renal histologic data. Am J Med. 1983;75:382–91.
Mac-Moune Lai F, Lai KN, Lee JCK, et al. Hepatitis B virus-related glomerulopathy in patients with systemic lupus erythematosus. Am J Clin Pathol. 1987;88:412–6.
D’Agati V, Seigle R. Coexistence of AIDS and lupus nephritis:a case report. Am J Nephrol. 1990;10:243–7.
Mac-Moune Lai F, Li EKM, Tang NLS, et al. IgA nephropathy: a rare lesion in systemic lupus erythematosus. Mod Pathol. 1995;8:5–10.
Nakamura H, Usa T, Motomura M, Ichikawa T, Nakao K, Kawasaki E, Tanaka M, Ishikawa K, Eguchi K. Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders. J Endocrinol Invest. 2008;31(10):861–5.
Byron MA, Mowat AG. Thyroid disorders in systemic lupus erythematosus. Ann Rheum Dis. 1987;46:174–5.
Vianna JL, Haga HJ, Asherson RA, et al. A prospective evaluation of antithyroid antibody prevalence in 100 patients with systemic lupus erythematosus. J Rheumatol. 1991;18:1193–5.
Pettersson T, Tornroth T, Totterman KJ, et al. AA amyloidosis in systemic lupus erythematosus. J Rheumatol. 1987;14:835–9.
Magasic MV, Venkataseshan VS, Vitting KE. Concurrent renal sarcoidosis and lupus nephritis. Nephron. 1993;64:496–7.
Ellington KT, Truong L, Oliviero JJ. Renal amyloidosis in systemic lupus erythematosus. Am J Kidney Dis. 1993;21:676–8.
Horino T, Takao T, Terada Y. IgA nephropathy in a patient with systemic lupus erythematosus. Lupus. 2010;19:650–4.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Kobak, S., Hudaverdı, O., Keser, G. et al. Coexistence of systemic lupus erythematosus, Hashimoto’s thyroiditis and IgA nephropathy in the same patient. Mod Rheumatol 21, 89–91 (2011). https://doi.org/10.1007/s10165-010-0345-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10165-010-0345-z