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Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey

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Abstract

Background

To prepare for a future clinical trial for improving the long-term prognosis of patients with uterine leiomyosarcoma (ULMS), we conducted a multi-institutional survey in the Tohoku region of Japan.

Methods

We conducted a retrospective cohort study between 2011 and 2014 in member institutions of the Tohoku Translational Research Center Development Network.

Results

A total of 53 patients with ULMS were registered in 31 institutions for the present survey. The median patient age was 56 years, 67.9% of the patients were postmenopausal, 88.7% had a performance status of 0 or 1, and only 6 patients (11.3%) showed preoperative evidence of malignancy. Although retroperitoneal lymphadenectomy was performed in only 26.4% of patients, 64.2% patients were identified as having FIGO stage 1 disease; 73.6% were eligible to undergo complete surgery. Among 36 patients who were treated with postoperative chemotherapy, 28 (77.8%) received docetaxel and gemcitabine combination therapy. The most frequent recurrence site was the lungs, and the median progression-free survival of all enrolled patients was 11.7 months. However, the median progression-free survival and the median overall survival in patients with stages III and IV disease were 3.4 and 11.4 months, respectively.

Conclusion

Although ULMS was associated with a high rate of complete or optimal surgery, the long-term prognosis was poor. Effective postoperative therapy should be developed to improve the long-term prognosis of patients with ULMS.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan

    Hideki Tokunaga, Hidekazu Nishigori & Nobuo Yaegashi

  2. Clinical Research, Innovation and Education Center, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Fumiaki Takahashi, Hiroaki Shimokawa & Yoh Watanabe

  3. Department of Obstetrics and Gynecology, Omagari Kousei Medical Center, 8-65 Omagaritori-machi, Daisen, Omagari, Akita, 014-0027, Japan

    Hiroki Yamamoto

  4. Department of Obstetrics and Gynecology, Iwaki Kyoritsu Hospital, 16 Uchigomimaya-machi, Iwaki, Fukushima, 973-8402, Japan

    Tsuyoshi Honda

  5. Department of Obstetrics and Gynecology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan

    Takafumi Watanabe

  6. Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan

    Tadahiro Shoji & Toru Sugiyama

  7. Department of Gynecology, Miyagi Cancer Center, 47-1 Medeshimashiote, Natori, Miyagi, 981-1293, Japan

    Hidekazu Yamada

  8. Department of Obstetrics and Gynecology, Hirosaki National Hospital, 1 Tomino-cho, Hirosaki, Aomori, 036-8545, Japan

    Tomoe Tando

  9. Department of Obstetrics and Gynecology, Sendai Medical Center, 2-8-8 Miyagino, Miyagino-ku, Sendai, Miyagi, 983-8520, Japan

    Kosuke Yoshinaga

  10. Department of Obstetrics and Gynecology, Nakadori General Hospital, 3-15 Minamidorimisono-cho, Akita, Akita, 010-8577, Japan

    Satoko Kagabu

  11. Department of Obstetrics and Gynecology, Sendai City Hospital, 1-1-1 Asutonagamachi, Taihaku-ku, Sendai, Miyagi, 982-8502, Japan

    Takeo Otsuki

  12. Department of Obstetrics and Gynecology, Takeda General Hospital, 3-27 Yamaga-machi, Aizuwakamatsu, Fukushima, 965-8585, Japan

    Shogo Kin

  13. Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan

    Yoshihito Yokoyama

  14. Department of Obstetrics and Gynecology, Osaki Citizen Hospital, 3-8-1 Furukawa, Osaki, Miyagi, 989-6183, Japan

    Satoshige Wagatsuma

  15. Department of Obstetrics and Gynecology, Iwate Prefectural Chubu Hospital, 17-10 Murasakino, Kitakami, Iwate, 024-8507, Japan

    Kazuyo Sato

  16. Department of Obstetrics and Gynecology, Japanese Red Cross Akita Hospital, 222-1 Kamikitatesaruta, Akita, Akita, 010-1495, Japan

    Hirokazu Sato

  17. Department of Obstetrics and Gynecology, Aomori Kousei Hospital, 488-1 Shinjyo, Aomori, Aomori, 038-0042, Japan

    Takashi Oishi

  18. Department of Obstetrics and Gynecology, Japanese Red Cross Ishinomaki Hospital, 71 Hebita, Ishinomaki, Miyagi, 986-8522, Japan

    Yuji Yoshida

  19. Department of Obstetrics and Gynecology, Nihonkai General Hospital, 30 Akiho-cho, Sakata, Yamagata, 998-8501, Japan

    Tadashi Hayasaka

  20. Department of Obstetrics and Gynecology, Noshiro Kousei Medical Center, Ochiai, Akita, Noshiro, 016-0014, Japan

    Toshihiko Matsui

  21. Department of Obstetrics and Gynecology, Hachinohe City Hospital, 1 Bisyamontai, Hachinohe, Aomori, Tamukai-aza, 031-8555, Japan

    Noriaki Imai

  22. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-Ku, Sendai, Miyagi, 980-8574, Japan

    Hiroaki Shimokawa

  23. Department of Obstetrics and Gynecology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-Ku, Sendai, Miyagi, 983-8512, Japan

    Yoh Watanabe

Authors
  1. Hideki Tokunaga
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  2. Fumiaki Takahashi
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  3. Hiroki Yamamoto
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  4. Tsuyoshi Honda
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  5. Takafumi Watanabe
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  6. Tadahiro Shoji
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  7. Toru Sugiyama
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  8. Hidekazu Yamada
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  9. Tomoe Tando
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  10. Kosuke Yoshinaga
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  11. Satoko Kagabu
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  12. Takeo Otsuki
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  13. Shogo Kin
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  14. Yoshihito Yokoyama
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  15. Satoshige Wagatsuma
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  16. Kazuyo Sato
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  17. Hirokazu Sato
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  18. Takashi Oishi
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  19. Yuji Yoshida
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  20. Tadashi Hayasaka
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  21. Toshihiko Matsui
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  22. Noriaki Imai
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  23. Hidekazu Nishigori
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  24. Hiroaki Shimokawa
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  25. Nobuo Yaegashi
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  26. Yoh Watanabe
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Corresponding author

Correspondence to Yoh Watanabe.

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Authors have no conflict of interest to declare.

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Tokunaga, H., Takahashi, F., Yamamoto, H. et al. Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey. Int J Clin Oncol 22, 541–547 (2017). https://doi.org/10.1007/s10147-017-1097-y

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  • DOI: https://doi.org/10.1007/s10147-017-1097-y

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