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CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1

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Abstract

As a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs recognition specifically and its mechanisms are diverse in different situations. With a view to developing certain antifungal targeted drugs, this review provides new insights into the novel immune signaling pathways induced by Dectin-1, especially the novel understandings of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB signaling pathway.

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Authors and Affiliations

  1. Department of Stomatology, Second Affiliated Hospital, Medicine College, Zhejiang University, Hangzhou, 310009, China

    H. Yang, H. He & Y. Dong

Authors
  1. H. Yang
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  2. H. He
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  3. Y. Dong
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Corresponding author

Correspondence to Y. Dong.

Additional information

This work is funded by the Research and Development Program of Science & Technology in Zhejiang of China 2008 C33026 and Zhejiang Medicine Hygiene Science Research 2009A098

Haiping Yang and Hong He are the co-first author, they have contributed equally to this work

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Yang, H., He, H. & Dong, Y. CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1. Eur J Clin Microbiol Infect Dis 30, 303–305 (2011). https://doi.org/10.1007/s10096-010-1103-z

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  • DOI: https://doi.org/10.1007/s10096-010-1103-z

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