Skip to main content
SpringerLink
Log in

Prevalence and genetic relatedness of community-acquired methicillin-resistant Staphylococcus aureus in Israel

  • Concise Article
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The aims of the study presented here were to determine the prevalence of Staphylococcus aureus carriage and, specifically, community-acquired methicillin-resistant S. aureus (CA-MRSA) carriage in children and their parents in Israel and to determine the genetic relatedness of these isolates. S. aureus was isolated from 580 of 3,373 (17.2%) individuals screened. The predominant type identified by pulsed-field gel electrophoresis was strain ST45-MSSA (25%). Five MRSA isolates were detected, and two of these were classified as CA-MRSA, based on the following criteria: no previous contact with a healthcare facility, absence of a multidrug-resistant (MDR) phenotype, and presence of SCCmec type IV. Isolates were negative for pvl and were classified as ST-45-MRSA. Although CA-MRSA is still rare in Israel, the genetic relatedness of the strains found in this study to a successful MSSA clone warrants close follow up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Cosgrove SE, Sakoulas G, Perencevich EN, Schwaber MJ, Karchmer AW, Carmeli Y (2003) Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylocccus aureus bacteremia: a meta-analysis. Clin Infect Dis 36:53–59

    Article  PubMed  Google Scholar 

  2. Netola N, Francis JS, Nuermberger EL, Bishai WR (2005) Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 5:275–286

    Article  Google Scholar 

  3. Vandenesch F, Naimi T, Enright MC et al (2003) Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton–Valentine leukocidin genes: worldwide emergence. Emerg Infect Dis 9:978–984

    PubMed  Google Scholar 

  4. Regev-Yochay G, Rubinstein E, Barzilai A, Carmeli Y, Kuint J, Etienne J, Blech M, Smollen G, Maayan-Metzger A, Leavitt A, Rahav G, Keller N (2005) Methicillin-resistant Staphylococcus aureus in neonatal intensive care unit. Emerg Infect Dis 11:453–456

    PubMed  Google Scholar 

  5. National Committee for Clinical Laboratory Standards (2005) Performance standards for antimicrobial susceptibility testing. Fifteenth informational supplement. M100-S15. NCCLS, Wayne, Pa

    Google Scholar 

  6. Schwaber MJ, Navon-Venezia S, Leavitt A, Mekuzas Y, Hammer-Munz O, Schlesinger J, Schwartz D, Carmeli Y (2004) Failure of broth-based tests to detect methicillin-resistant Staphylococcus aureus in a clinical specimen. Eur J Clin Microbiol Infect Dis 23:348–351

    Article  PubMed  CAS  Google Scholar 

  7. Oliveira DC, de Lencastre H (2002) Multiplex PCR strategy for rapid identification of structural types anc variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 46:2155–2161

    Article  PubMed  CAS  Google Scholar 

  8. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG (2000) Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 38:1008–1015

    PubMed  CAS  Google Scholar 

  9. Jarraud S, Mougel C, Thiolouse J, Lina G, Meugnier H, Forey F et al (2002) Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles) and human disease. Infect Immun 70:631–641

    Article  PubMed  CAS  Google Scholar 

  10. Okuma K, Iwakawa K, Turnidge JD et al (2002) Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J Clin Microbiol 40:4289–4294

    Article  PubMed  CAS  Google Scholar 

  11. Enright MC, Ashley Robinson DA, Randle G, Feil EJ, Grundmann H, Spratt BG (2002) The evolutionary history of methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci USA 99:7687–7692

    Article  PubMed  CAS  Google Scholar 

  12. Aires de Sousa M, de Lencastre H (2003) Evolution of sporadic isolates of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and their similarities to isolates of community-acquired MRSA. J Clin Microbiol 42:3806–3815

    Article  Google Scholar 

  13. Charlebois ED, Perdreau-Remington F, Kreiswirth B, Bangsberg DR, Ciccarone D, Diep BA, Ng VL, Chansky K, Edlin B, Chambers HF (2004) Origins of community strains of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 39:47–54

    Article  PubMed  CAS  Google Scholar 

  14. Holden MT, Feil EF, Lindsay JA et al (2004) Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci USA 101:9786–9791

    Article  PubMed  CAS  Google Scholar 

  15. Wannet WJB, Spalburg E, Heck MEOC, Pluister GN, Willems RJL, de Neeling AJ (2004) Widespread dissemination in the Netherlands of the epidemic Berlin methicillin-resistant Staphylococcus aureus clone with low-level resistance to oxacillin. J Clin Microbiol 42:3077–3082

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank the participating physicians from Hashfela District of Macabbi Healthcare Services (the IJAP Maccabi study group) for their cooperation and help in recruiting the study population. Guidelines for human experimentation in clinical research were followed. Financial support for this study was provided by the Chief Scientist Office, Israeli Ministry of Health and by Maccabi Healthcare Services.

Author information

Author notes

  1. G. Regev-Yochay

    Present address: Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA

Authors and Affiliations

  1. Infectious Diseases Unit, Sheba Medical Center, Ramat-Gan, Israel

    G. Regev-Yochay & E. Rubinstein

  2. Sackler Medical School, Tel-Aviv University, Tel-Aviv, Israel

    G. Regev-Yochay, Y. Carmeli, E. Rubinstein & S. Navon-Venezia

  3. Division of Epidemiology and Laboratory for Molecular Epidemiology and Antimicrobial Research, Tel Aviv Medical Center, Tel-Aviv, Israel

    Y. Carmeli, A. Leavitt & S. Navon-Venezia

  4. Maccabi Healthcare Services, Rishon-Lezion, Israel

    M. Raz & E. Pinco

  5. Faculte de Medecine Laennec, INSERM E0230, Lyon, France

    J. Etienne

Authors
  1. G. Regev-Yochay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Carmeli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Raz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. Pinco
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Etienne
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. Leavitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. Rubinstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. Navon-Venezia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Regev-Yochay.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Regev-Yochay, G., Carmeli, Y., Raz, M. et al. Prevalence and genetic relatedness of community-acquired methicillin-resistant Staphylococcus aureus in Israel. Eur J Clin Microbiol Infect Dis 25, 719–722 (2006). https://doi.org/10.1007/s10096-006-0210-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-006-0210-3

Keywords

Search

Navigation