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Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin

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Abstract

Current theory or hypothesis relevant to migraine indicates that trigeminovascular system plays a pivotal role in the pathophysiology of migraine. Particularly, release of neuropeptide and induction of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons are regarded as activation markers of trigeminovascular system. In the present study, we set up a rat model for migraine triggered by nitroglycerin (NTG) and coagulated the middle meningeal artery by heating. Using this model, we determined the plasma calcitonin gene-related peptide (CGRP) level as well as the expression of c-fos in trigeminal nucleus caudalis of rats. We found that NTG led to markedly increase in plasma CGRP level and c-fos expression in trigeminal nucleus caudalis compared with the isotonic saline-treated group (P < 0.05). More importantly, heat coagulation of middle meningeal artery could decrease plasma CGRP level and c-fos expression in trigeminal nucleus caudalis (P < 0.05). Heat coagulation of middle meningeal artery may ameliorate sufferings of rat induced by NTG and play an important role in restraining the release of CGRP as well as the activation of neurons in trigeminal nucleus caudalis in rats following NTG infusion.

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Acknowledgments

This study was supported by the Foundation of Science and Technology of Shandong Province (No: 2007GG2002).

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Authors and Affiliations

  1. Otolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, People’s Republic of China

    Xiaofeng Zhu, Yuechen Han, Wenping Xiong, Haibo Wang & Zhaomin Fan

  2. Institute of Eye and ENT, Shandong Clinic Research Institute, Jinan, People’s Republic of China

    Wenwen Liu, Sumei Lu, Jianfeng Li & Haibo Wang

Authors
  1. Xiaofeng Zhu
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  2. Yuechen Han
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  3. Wenping Xiong
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  4. Wenwen Liu
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  5. Sumei Lu
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  6. Jianfeng Li
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  7. Haibo Wang
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  8. Zhaomin Fan
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Corresponding author

Correspondence to Zhaomin Fan.

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X. Zhu and Y. Han contributed equally to this work.

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Zhu, X., Han, Y., Xiong, W. et al. Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin. Neurol Sci 32, 589–594 (2011). https://doi.org/10.1007/s10072-011-0486-7

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  • DOI: https://doi.org/10.1007/s10072-011-0486-7

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