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Poncet’s disease (reactive arthritis associated with tuberculosis): retrospective case series and review of literature

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Abstract

The primary objective of this study is to describe the demographics and clinical characteristics of patients with Poncet’s disease (PD) in the Makkah region in Saudi Arabia, where tuberculosis is on the rise. The secondary objective is conducting a PD systematic literature review to compare our findings. We studied seven patients who presented with arthritis within the first 3 years from diagnosis of active tuberculosis in two centers in the Makkah region: King Faisal Specialist Hospital and King Fahad Hospital in Jeddah from January 2005 to December 2011. We conducted a literature review on PD in multiple biomedical/pharmaceutical databases up to December 2011. We detected a new pattern of reactive arthritis associated with tuberculosis (TB). We identified this as PD or tuberculous rheumatism, which is a sterile reactive arthritis that can emerge during any stage of acute TB infection. Seven cases of Poncet’s disease were identified in our study. The most common presentation was extrapulmonary with involvement of multiple sites. Six out of seven patients developed arthritis after initiation of anti-TB drugs; one patient developed polyarthritis after completion of anti-TB medication. Asymmetrical polyarthritis was the most common presentation and the resolution of the arthritis was with symptomatic treatment and continuation of anti-TB drugs except in one case. PD may manifest in a variable pattern during the course of active tuberculous infection. Physicians should be aware of this rare complication associated with a common disease to prevent delay in diagnosis and initiation of appropriate treatment.

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Acknowledgments

The study was supported and funded by Alzaidi’s Chair of Research in Rheumatic Diseases, Umm Alqura University. The authors would like to acknowledge Dr Khatijah Bawazeer for her help provided during the manuscript preparation and Dr Alyaa Khodarwardi for her help provided in the data collection.

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Authors and Affiliations

  1. Rheumatology Unit, Department of Medicine, King Fahad Hospital, Jeddah, Saudi Arabia

    Sultana Abdulaziz

  2. Department of Medicine, Umm Alqura University, Makkah, Saudi Arabia

    Hani Almoallim, Mohammed Samannodi, Mohammed Shabrawishi, Ghadi Abdulmajeed, Ghadeer Banjar, Weam Qutub & Hiba Dowaikh

  3. Department of Medicine, King Faisal Specialist Hospital, Jeddah, Saudi Arabia

    Hani Almoallim & Yasir Meeralam

  4. Alzaidi chair of research in rheumatic diseases, Umm Alqura University, Makkah, Saudi Arabia

    Ashraf Ibrahim

Authors
  1. Sultana Abdulaziz
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  2. Hani Almoallim
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  3. Ashraf Ibrahim
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  4. Mohammed Samannodi
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  5. Mohammed Shabrawishi
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  6. Yasir Meeralam
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  7. Ghadi Abdulmajeed
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  9. Weam Qutub
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  10. Hiba Dowaikh
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Correspondence to Sultana Abdulaziz.

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Abdulaziz, S., Almoallim, H., Ibrahim, A. et al. Poncet’s disease (reactive arthritis associated with tuberculosis): retrospective case series and review of literature. Clin Rheumatol 31, 1521–1528 (2012). https://doi.org/10.1007/s10067-012-2042-0

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  • DOI: https://doi.org/10.1007/s10067-012-2042-0

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