Skip to main content
SpringerLink
Log in

Combined thrombophilic factors increase the risk of recurrent thrombotic events in Behcet’s disease

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

This retrospective study aims to seek a relationship between the number of thrombotic events and presence of thrombophilic factors in Behcet’s disease (BD). Any patient with a vascular problem evaluated for at least one thrombophilic factor was deemed eligible for the present study. Upon an evaluation of their medical records, 96 (23.9%) of the 402 patients diagnosed with BD were determined to have a history of thrombosis. Of these 96 patients, 72 (75%) had only one thrombotic attack, while the remaining 24 (25%) had two or more thrombotic attacks. Thrombophilic parameters were evaluated in only 36 of the 72 patients (50%) who had one thrombotic event (Group I) and in 18 of the 24 patients (75%) who had more than one thrombotic event (Group II). The patients with recurrent thrombotic events had a significantly higher incidence of combined thrombophilias than those patients with only one thrombotic event (8/18, 44%; 4/36, 11%; p < 0.01). The number of the patients free from thrombophilic risk factors was significantly higher in Group I than in Group II (21/36, 58%; 4/18, 22%; p < 0.02). Group II had an increased frequency of combined thrombophilic risk factors (OR 6.4; 95% CI 1.5–25.8) when compared to Group I. No significant differences were found between Groups I and II with respect to clinical features of BD. In conclusion, combined thrombophilias in patients with BD may have a role in the development of recurrent thrombotic events.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Lee YJ, Kang SW, Yang JI et al (2002) Coagulation parameters and plasma total homocysteine levels in Behçet’s disease. Thromb Res 106:19–24

    Article  CAS  PubMed  Google Scholar 

  2. Lenk N, Ozet G, Alli N et al (1997) Protein C and protein S activities in Behçet’s disease as risk factors of thrombosis. Int J Dermatol 37:124–125

    Article  Google Scholar 

  3. Leiba M, Sidi Y, Gur H et al (2001) Behçet’s disease and thrombophilia. Ann Rheum Dis 60:1081–1085

    Article  CAS  PubMed  Google Scholar 

  4. Yurdakul S, Yazici H (2008) Behçet’s syndrome. Baillieáre’s Best Pract Res Clin Rheumatol 22:793–809

    Article  Google Scholar 

  5. Leiba M, Seligsohn U, Sidi Y et al (2004) Thrombophilic factors are not the leading cause of thrombosis in Behçet’s disease. Ann Rheum Dis 63:1445–1449

    Article  CAS  PubMed  Google Scholar 

  6. Durieux P, Bletry O, Huchon G, Wechsler B, Chretien J, Godeau P (1981) Multiple pulmonary arterial aneurysms in Behcet’s disease and Hughes-Stovin syndrome. Am J Med 71:736–741

    Article  CAS  PubMed  Google Scholar 

  7. Mammo L, Al-Dalaan A, Bahabri SS, Saour JN (1997) Association of factors V leiden with Behcet’s Disease. J Rheumatol 24:2196–2198

    CAS  PubMed  Google Scholar 

  8. Gül A, Ozbek U, Oztürk C et al (1996) Coagulation factor V gene mutation increases the risk of venous thrombosis in behçet’s disease. Br J Rheumatol 35:1178–1180

    Article  PubMed  Google Scholar 

  9. Oner AF, Gürgey A, Gürler A, Mesci L (1998) Factor V Leiden mutation in patients with Behçet’s disease. J Rheumatol 25:496–498

    CAS  PubMed  Google Scholar 

  10. Siliagardi M, Ghirarduzzi A, Lori L et al (2001) Factor V leiden and G20210A prothrombin alleles are not associated with thrombosis in Behçet’s disease. Thromb Haemost 85(suppl):2519

    Google Scholar 

  11. Wechsler B, Davatchi F, Hamza M et al (1990) Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s disease. Lancet 335:1078–1080

    Google Scholar 

  12. Hampton KK, Chamberlain MA, Menon DK, Davies JA (1991) Coagulation and fibrinolytic activity in Behçet’s disease. Thromb Haemost 66:292–294

    CAS  PubMed  Google Scholar 

  13. Koşar A, Haznedaroğlu IC, Büyükaşik Y et al (1998) Activated protein C resistance in Behçet’s disease. Rheumatol Int 17:249–250

    Article  PubMed  Google Scholar 

  14. Toydemir PB, Elhan AH, Tükün A et al (2000) Effects of factor V gene G1691A, methylenetetrahydrofolate reductase gene C677T, and prothombin gene G20210A mutations on deep venous thrombogenesis in Behçet’s disease. J Rheumatol 27:2849–2854

    CAS  PubMed  Google Scholar 

  15. Orem A, Deger O, Memis O et al (1995) Lp(a) lipoprotein levels as a predictor of risk for thrombogenic events in patients with Behcet’s disease. Ann Rheum Dis 54:726–729

    Article  CAS  PubMed  Google Scholar 

  16. Korkmaz C, Kasifoglu T, Kebapcı M (2007) Budd-Chiari syndrome in the course of Behcet’s disease: clinical and laboratory analysis of four cases. Jt Bone Spine 74:245–248

    Article  Google Scholar 

  17. Saadoun D, Rvechsler B, Resche-Rigon M et al (2009) Cerebral venous thrombosis in Behcet’s disease. Arthritis Rheum 61:518–526

    Article  CAS  PubMed  Google Scholar 

  18. de Stefano V, Martinelli I, Mannucci PM et al (1999) The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation. N Engl J Med 41:801–806

    Article  Google Scholar 

  19. Simioni P, Prandoni P, Lensing AWA et al (1997) The risk of recurrent venous thromboembolism in patients with an Arg506Gln mutation in the gene for factor V (Factor V Leiden). N Engl J Med 336:399–403

    Article  CAS  PubMed  Google Scholar 

  20. Korkmaz C (2008) Is anticoagulation unnecessary in Behcet’s disease with deep venous thrombosis? Clin Rheumatol 27:405–406

    Article  PubMed  Google Scholar 

Download references

Disclosures

None.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Turkey

    N. Şule Yaşar, Füsun Salgür, Döndü Ü. Cansu, Timuçin Kaşifoğlu & Cengiz Korkmaz

Authors
  1. N. Şule Yaşar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Füsun Salgür
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Döndü Ü. Cansu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Timuçin Kaşifoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cengiz Korkmaz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cengiz Korkmaz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yaşar, N.Ş., Salgür, F., Cansu, D.Ü. et al. Combined thrombophilic factors increase the risk of recurrent thrombotic events in Behcet’s disease. Clin Rheumatol 29, 1367–1372 (2010). https://doi.org/10.1007/s10067-010-1455-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-010-1455-x

Keywords

Search

Navigation