Skip to main content
SpringerLink
Log in

Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures

  • ORIGINAL PAPER
  • Published:
Medical Molecular Morphology Aims and scope Submit manuscript

Abstract

A 59-year-old Japanese man presented with a giant submucosal tumor with ulceration during follow-up of duodenal ulcer. Pancreaticoduodenectomy was undertaken, and subsequent histological examination of the tumor disclosed anaplastic carcinoma of the pancreas head. The carcinoma components contained adenocarcinoma and squamous cell carcinoma. Additionally, undifferentiated spindle or pleomorphic cells were seen in continuity with the carcinoma component. Undifferentiated neoplastic cells with rhabdoid features and with hyaline globule-like structures positive for PAS stain with diastase pretreatment were also observed. Immunohistochemically, cytoplasmic inclusions corresponding to rhabdoid features showed aggregates of vimentin. Ultrastructurally, hyaline globule-like structures corresponded to lysosomes. Finally, we report here the first case of anaplastic carcinoma of the pancreas with hyaline globule-like structures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E Paal LDR Thompson RA Frommelt RM Przygodzki CS Heffess (2001) ArticleTitleA clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature Ann Diagn Pathol 5 129–140 Occurrence Handle11436166 Occurrence Handle10.1053/adpa.2001.25404 Occurrence Handle1:STN:280:DC%2BD3MznvVOmsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. N Kuroda T Sawada E Miyazaki Y Hayashi M Toi K Naruse T Fukui H Nakayama M Hiroi H Taguchi H Enzan (2000) ArticleTitleAnaplastic carcinoma of the pancreas with rhabdoid features Pathol Int 50 57–62 Occurrence Handle10692179 Occurrence Handle10.1046/j.1440-1827.2000.00996.x Occurrence Handle1:STN:280:DC%2BD3c7ls1WitA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  3. E Solcia C Capella G Kloppel (1997) Undifferentiated (anaplastic) carcinoma. Tumors of the pancreas Atlas of tumor pathology, 3rd series Armed Forces Institute of Pathology Washington, DC 91–93

    Google Scholar 

  4. MD Perez-Montiel WL Frankel S Suster (2003) ArticleTitleNeuroendocrine carcinoma of the pancreas with “rhabdoid” features Am J Surg Pathol 27 642–649 Occurrence Handle12717248 Occurrence Handle10.1097/00000478-200305000-00007

    Article  PubMed  Google Scholar 

  5. R Chetty SL Asa (2004) ArticleTitlePancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term “rhabdoid” appropriate? J Clin Pathol 57 1106–1110 Occurrence Handle15452172 Occurrence Handle10.1136/jcp.2004.018309 Occurrence Handle1:STN:280:DC%2BD2cvotlaltg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  6. N Kuroda H Satake E Miyazaki Y Hayashi H Hiroi H Enzan (2004) ArticleTitleCollecting duct carcinoma exhibiting diastase-resistant PAS-positive globular cytoplasmic inclusions and rhabdoid features in adult polycystic kidney disease: a case report Int J Surg Pathol 12 171–177 Occurrence Handle15173927 Occurrence Handle10.1177/106689690401200215

    Article  PubMed  Google Scholar 

  7. N Danbara N Shikata H Kawamura M Shintaku A Tsubura (2005) ArticleTitleEosinophilic cytoplasmic inclusions in papillary renal cell carcinoma Med Mol Morphol 38 262–266 Occurrence Handle16378236 Occurrence Handle10.1007/s00795-005-0286-3 Occurrence Handle1:CAS:528:DC%2BD2MXhtlGhsLnN

    Article  PubMed  CAS  Google Scholar 

  8. AD Rosario HX Bui J Singh R Ginsburg JS Ross (1994) ArticleTitleIntracytoplasmic eosinophilic hyaline globules in cartilaginous neoplasms: a surgical, pathological, ultrastructural, and electron probe X-ray microanalytic study Hum Pathol 25 1283–1289 Occurrence Handle7528163 Occurrence Handle10.1016/0046-8177(94)90086-8

    Article  PubMed  Google Scholar 

  9. CL Dai F Xu H Shu YQ Xu Y Huang (2005) ArticleTitleUndifferentiated (embryonal) sarcoma of liver in adult: a case report World J Gastroenterol 11 926–929 Occurrence Handle15682496

    PubMed  Google Scholar 

  10. C Stumptner H Heid A Fuchsbichler H Hauser HJ Mischiger K Zatloukal H Denk (1995) ArticleTitleAnalysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma Am J Pathol 154 1701–1710

    Google Scholar 

  11. R Gonzalez-Campora AG Escudero JJR Martin JRA Pardon AH Vazquez FJV Ramirez (2003) ArticleTitleMyofibrosarcoma (low-grade myofibroblastic sarcoma) with intracytoplasmic hyaline (fibroma-like) inclusion bodies Ultrastruct Pathol 27 7–11 Occurrence Handle12554531 Occurrence Handle10.1080/01913120309942

    Article  PubMed  Google Scholar 

  12. B Krishnan LD Truong (2002) ArticleTitleRenal epithelial neoplasms: the diagnostic implications of electron microscopic study in 55 cases Hum Pathol 33 68–79 Occurrence Handle11823975 Occurrence Handle10.1053/hupa.2002.30210

    Article  PubMed  Google Scholar 

  13. MG Weaver FW Abdul-Karim J Srigley DG Bostwick JY Ro AG Ayala (1992) ArticleTitlePaneth cell-like change of the prostatic gland. A histological, immunohistochemical, and electron microscopic study Am J Surg Pathol 16 62–68 Occurrence Handle1370193 Occurrence Handle1:STN:280:DyaK38%2FpsFCiuw%3D%3D Occurrence Handle10.1097/00000478-199201000-00009

    Article  PubMed  CAS  Google Scholar 

  14. N Kuroda Y Inui M Ohara T Hirouchi K Mizuno A Kubo Y Hayashi H Enzan GH Lee (2007) ArticleTitleHyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the Fallopian tube Med Mol Morphol 40 46–49 Occurrence Handle17384990 Occurrence Handle10.1007/s00795-006-0327-6

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi City, Kochi, 780-8562, Japan

    Naoto Kuroda, Masahiko Ohara, Takashi Hirouchi & Keiko Mizuno

  2. Department of Internal Medicine, Kochi Red Cross Hospital, Kochi, Japan

    Shin-ichi Iwamura

  3. Department of Surgery, Kochi Red Cross Hospital, Kochi, Japan

    Nokiaki Fujishima

  4. Department of Pathology, Program of Bioregulation and Genetics, Kochi Medical School, Kochi University, Kochi, Japan

    Yoshihiro Hayashi & Gang-Hong Lee

Authors
  1. Naoto Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shin-ichi Iwamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nokiaki Fujishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masahiko Ohara
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Hirouchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Keiko Mizuno
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yoshihiro Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gang-Hong Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naoto Kuroda.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuroda, N., Iwamura, Si., Fujishima, N. et al. Anaplastic carcinoma of the pancreas with rhabdoid features and hyaline globule-like structures. Med Mol Morphol 40, 168–171 (2007). https://doi.org/10.1007/s00795-006-0349-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00795-006-0349-0

Key words

Search

Navigation