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Genomic detection of human immunodeficiency virus (HIV) by nucleic acid amplification test in a frequent platelet donor during the pre-seroconversion period

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Abstract

Since serological donor-screening tests for HIV were introduced in 1985, the safety of donated blood components has improved dramatically. However, these tests do not completely prevent the risk of transfusion-associated HIV infection related to the use of blood donated during the pre-seroconversion window period. Testing based on nucleic acid amplification is being implemented to screen for HIV-infected blood donated during this period, which has reduced the probability of transmitting HIV through transfusion by shortening the window period. This article describes a case of acute HIV-1 infection, detected using a nucleic acid amplification test (NAT) in a repeat blood donor who donated during the pre-seroconversion window period and whose antigen and anti-HIV antibody expression was observed after molecular marker detection. In addition, the possible route of infection is discussed based on the patient’s history, and finally, the need for NAT technology for blood donor screening is emphasized.

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Authors and Affiliations

  1. Laboratório de Virologia Humana, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 7A Edifício RIOL, N° 158, 1° andar, sala 101, setor aeroporto, 74-075-030, Goiânia, Goiás, Brasil

    Robério Amorim de Almeida Pondé

  2. Central Goiana de Sorologia, Imuno-hematologia e Biologia Molecular, Goiânia, Goiás, Brasil

    Robério Amorim de Almeida Pondé

  3. Hospital Materno-Infantil, Goiânia, Goiás, Brasil

    Robério Amorim de Almeida Pondé

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  1. Robério Amorim de Almeida Pondé
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Correspondence to Robério Amorim de Almeida Pondé.

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Pondé, R.A.A. Genomic detection of human immunodeficiency virus (HIV) by nucleic acid amplification test in a frequent platelet donor during the pre-seroconversion period. Arch Virol 156, 2085–2090 (2011). https://doi.org/10.1007/s00705-011-1085-x

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  • DOI: https://doi.org/10.1007/s00705-011-1085-x

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