Abstract
Memantine is an N-methyl-d-aspartate (NMDA) receptor antagonist, approved for the treatment of moderate to severe Alzheimer’s disease (AD). We conducted a 4-month observational, post-marketing, Austrian study of memantine in 377 outpatients with moderate to severe AD. In this ‘real-life’ setting, memantine was well-tolerated, and produced benefits in cognition (Mini-Mental State Examination), activities of daily living (Activities of Daily Living score), and global function (Clinical Global Impression scale). Treatment effects were apparent in both pre-treated and treatment-naïve patient subgroups.
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This work was supported by a grant from Merz Pharmaceuticals GmbH, Germany.
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Rainer, M., Wuschitz, A., Jagsch, C. et al. Memantine in moderate to severe Alzheimer’s disease: an observational post-marketing study. J Neural Transm 118, 1255–1259 (2011). https://doi.org/10.1007/s00702-011-0623-8
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DOI: https://doi.org/10.1007/s00702-011-0623-8