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Repeat hepatectomies for hepatic malignant lymphoma and hepatocellular carcinoma associated with chronic hepatitis C: report of a case

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Abstract

We report a case of repeat hepatectomies for hepatic malignant lymphoma and hepatocellular carcinoma (HCC). A 75-year-old man with chronic hepatitis C underwent partial hepatectomy for a 25 mm hepatic tumor in S5. The histological diagnosis was diffuse large B-cell malignant lymphoma and as postoperative 18F-fluorodeoxyglucose-positron emission tomography showed no hot spots, the mass was presumed to be primary hepatic lymphoma. Thus, adjuvant systemic chemotherapy was given following the hepatectomy. Abdominal ultrasonography, done 12 months after the hepatectomy, showed a hepatic tumor in S6 and repeat partial hepatectomy was performed. This tumor was histologically diagnosed as HCC.

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Abbreviations

US:

Ultrasonography

HCC:

Hepatocellular carcinoma

HCV:

Hepatitis C virus

NHL:

Non-Hodgkin’s lymphoma

CT:

Computed tomography

MRI:

Magnetic resonance imaging

Gd-EOB-DTPA:

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid

AFP:

α-Fetoprotein

PIVKA 2:

Protein induced by vitamin K absence or antagonist-2

References

  1. Silvestri F, Barillari G, Fanin R, et al. The genotype of the hepatitis C virus in patients with HCV-related B-cell non-Hodgkin’s lymphoma. Leukemia. 1997;11:2157–61.

    Article  CAS  PubMed  Google Scholar 

  2. Kitabayashi K, Hasegawa T, Ueno K, et al. Primary hepatic lymphoma in a patient with chronic hepatitis C: report of a case. Surg Today. 2004;34:366–9.

    Article  PubMed  Google Scholar 

  3. Umemura T, Kiyosawa K et al. Epidemiology of hepatocellular carcinoma in Japan. Hepatol Res. 2007;37:S95–S100.

    Google Scholar 

  4. Fassio E. Hepatitis C and hepatocellular carcinoma. Ann Hepatol. 2010;9:119–22.

    PubMed  Google Scholar 

  5. Imai Y, Ohsawa M, Tanaka H, et al. HCV infection and non-Hodgkin’s lymphoma. Gastroenterology. 2002;34:364–6.

    Google Scholar 

  6. Suriawainata A, Ye MQ, Emre S, et al. Hepatocellular carcinoma and non-Hodgkin lymphoma in a patient with chronic hepatitis C and cirrhosis. Arch Pathol Lab Med. 2000;124:1532–4.

    Google Scholar 

  7. Shapira MY, Muszkat M, Braustein I, et al. Co-occurrence of hepatocellular carcinoma and lymphoma in patients with hepatitis C virus cirrhosis. J Clin Gastroenterol. 2001;32:1368–9.

    Article  Google Scholar 

  8. Mele A, Pulson A, Bianco E, et al. Hepatitis C virus and B-cell non Hodgkin lymphomas. An Italian multicenter case-control study. Blood. 2003;102:996–9.

    Article  CAS  PubMed  Google Scholar 

  9. Talmani R, Montella M, Crovatto M, et al. Non-Hodgkin’s lymphoma and hepatitis C virus. A case–control study from northern and southern Italy. Int J Cancer. 2004;110:380–5.

    Article  Google Scholar 

  10. Hermine O, Lefrère F, Bronowicki JP, et al. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection. N Engl J Med. 2002;347:89–94.

    Article  CAS  PubMed  Google Scholar 

  11. Quinn ER, Chan CH, Hadlock KG, et al. The B-cell receptor of a hepatitis C virus(HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis. Blood. 2001;98:3745–9.

    Article  CAS  PubMed  Google Scholar 

  12. Shapira MY, Muszkat M, Braunstein I, Gotsman I. Cooccurrence of hepatocellular carcinoma and lymphoma in patients with hepatitis C virus cirrhosis. J Clin Gastroenterol. 2001;32:368–9.

    Article  CAS  PubMed  Google Scholar 

  13. Himoto T, Miyauchi Y, Nomura K, Fushitani T, Kurokohchi K, Masaki T, et al. Coexistence of splenic non-Hodgkin’s lymphoma with hepatocellular carcinoma in a patient with chronic hepatitis C. Dig Dis Sci. 2006;51:70–6.

    Article  PubMed  Google Scholar 

  14. Lin A, Kadam JS, Bodenheimer HC, Leonard J, Joyce MA, Lake-Bkaar G. Concomitant diffuse large B-cell lymphoma and hepatocellular carcinoma in chronic hepatitis C virus liver disease: a study of two cases. J Med Virol. 2008;80:1350–3.

    Article  CAS  PubMed  Google Scholar 

  15. Kataoka TR, Tsukamoto Y, Kanazawa N, Izumi T, Awata N, Nishizawa Y, et al. Concomitant hepatocellular carcinoma and non-Hodgkin’s lymphoma in a patient with nodular regenerative hyperplasia. Pathol Int. 2006;56:279–82.

    Article  PubMed  Google Scholar 

  16. Talmo TS, Dekker A, Gurecki J, et al. Primary hepatic malignant lymphoma: its occurrence in a patient with chronic active hepatitis, cirrhosis, and hepatocellular carcinoma associated with hepatitis B virus infection. Cancer. 1980;46:336–9.

    Article  Google Scholar 

  17. Shikuwa S, Ito M, Nakashima M, et al. Autopsy case of colocalized tumors of hepatocellular carcinoma and malignant lymphoma. J Gastroenterol. 1996;31:129–32.

    Article  CAS  PubMed  Google Scholar 

  18. Cavanna L, Civardi G, Fornari F, et al. Simultaneous relapse of liver cell carcinoma and non-Hodgkin’s lymphoma in the liver. Report of a case with diagnosis by ultrasonically guided fine needle aspiration biopsy. Acta Cytol. 1994;38:451–4.

    CAS  PubMed  Google Scholar 

  19. Uthunomiya T, Okamoto M, Tsujita E, et al. Hepatocellular carcinoma infiltrated with non-Hodgkin’s lymphoma: report of a case. Surg Today. 2009;39:1010–2.

    Article  Google Scholar 

  20. Ryan J, Straus DJ, Lange C, et al. Primary lymphoma of the liver. Cancer. 1988;61:370–5.

    Article  CAS  PubMed  Google Scholar 

  21. Daniel S, Attiyeh FF, Dire JJ, et al. Primary lymphoma of the liver with extended left lobectomy. Cancer. 1985;55:206–9.

    Article  CAS  PubMed  Google Scholar 

  22. Taketomi A, Takenaka K, Shirabe K, et al. Surgically treated primary malignant lymphoma of the liver. Hepatogastroenterology. 1996;43:651–7.

    CAS  PubMed  Google Scholar 

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Conflict of interest

H. Tajiri and co-authors have no conflict of interest.

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Authors and Affiliations

  1. Department of Surgery, Steel Memorial Yawata Hospital, 1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, 805-8508, Japan

    Hirotada Tajiri, Keishi Sugimachi, Nao Kinjo, Masahiko Ikebe, Junko Tanaka, Kiyoshi Tanaka, Shuichi Tsukamoto, Shinsuke Mii & Hidefumi Higashi

  2. Department of Hepatology, Steel Memorial Yawata Hospital, 1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, 805-8508, Japan

    Eiji Kajiwara

  3. Department of Pathology, Steel Memorial Yawata Hospital, 1-1-1 Harunomachi, Yahatahigashi-ku, Kitakyushu, 805-8508, Japan

    Tatsuro Shimokama

Authors
  1. Hirotada Tajiri
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  2. Keishi Sugimachi
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  3. Nao Kinjo
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  4. Masahiko Ikebe
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  5. Junko Tanaka
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  6. Kiyoshi Tanaka
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  7. Shuichi Tsukamoto
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  8. Shinsuke Mii
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  9. Eiji Kajiwara
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  10. Tatsuro Shimokama
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  11. Hidefumi Higashi
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Correspondence to Keishi Sugimachi.

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Tajiri, H., Sugimachi, K., Kinjo, N. et al. Repeat hepatectomies for hepatic malignant lymphoma and hepatocellular carcinoma associated with chronic hepatitis C: report of a case. Surg Today 44, 188–191 (2014). https://doi.org/10.1007/s00595-013-0502-z

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  • DOI: https://doi.org/10.1007/s00595-013-0502-z

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