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Efficacy of perioperative administration of long-acting bronchodilator on postoperative pulmonary function and quality of life in lung cancer patients with chronic obstructive pulmonary disease. Preliminary results of a randomized control study

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Abstract

Purpose

Long-acting bronchodilators are recommended as a first-line treatment for chronic obstructive pulmonary disease (COPD), although their effects for postoperative lung cancer patients with COPD are still not well known. A prospective randomized trial was used to examine the efficacy of bronchodilators on postoperative pulmonary function and quality of life (QOL).

Methods

Twenty lung cancer patients with COPD who had lobectomies were randomized. A control group (n = 10) did not receive bronchodilators. An experimental group (n = 10) received tiotropium and salmeterol. Patients were divided into two COPD grades: stage I COPD and stage II–III COPD. Results for pulmonary function, 6-minute walking test, and the St. George’s Respiratory Questionnaire (SGRQ) were compared. Diaphragmatic motion on dynamic magnetic resonance imaging was also analyzed.

Results

The patient demographics were similar in the two groups. Except for pulmonary function results at 2 weeks, no other parameters were significantly different. However, in stage II–III COPD, forced expiratory volume in 1 second, forced vital capacity, inspiratory capacity, the total score of the SGRQ, and diaphragmatic motion in the experimental group (n = 5) were significantly better than those in the control group (n = 4) at various time points (all P < 0.05).

Conclusion

The daily inhalation of bronchodilators was effective for maintaining the respiratory function and QOL in lung cancer patients with moderate to severe COPD.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Chiba University, Chiba, Japan

    Hidemi Suzuki, Yasuo Sekine, Shigetoshi Yoshida, Makoto Suzuki, Kiyoshi Shibuya & Ichiro Yoshino

  2. Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Yuichi Takiguchi & Koichiro Tatsumi

  3. Department of Thoracic Surgery, Tokyo Women’s Medical University, Yachiyo Medical Center, 477-96 Owada Shinden, Yachiyo, Chiba, 276-8524, Japan

    Hidemi Suzuki & Yasuo Sekine

Authors
  1. Hidemi Suzuki
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  2. Yasuo Sekine
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  3. Shigetoshi Yoshida
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  4. Makoto Suzuki
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  5. Kiyoshi Shibuya
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  6. Yuichi Takiguchi
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  7. Koichiro Tatsumi
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  8. Ichiro Yoshino
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Additional information

The first (H.S.) and the second (Y.S.) authors contributed equally to this paper, and both are considered as first co-authors.

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Suzuki, H., Sekine, Y., Yoshida, S. et al. Efficacy of perioperative administration of long-acting bronchodilator on postoperative pulmonary function and quality of life in lung cancer patients with chronic obstructive pulmonary disease. Preliminary results of a randomized control study. Surg Today 40, 923–930 (2010). https://doi.org/10.1007/s00595-009-4196-1

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  • DOI: https://doi.org/10.1007/s00595-009-4196-1

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