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Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly

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Abstract:

A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His liver injury resembled that in autoimmune hepatitis. He was diagnosed with Epstein-Barr virus (EBV) infection associated with autoimmunization because of his clinical course, fluctuation of anti EBV antibodies and positive EBV genome in circulating lymphocytes and serum. This case suggests a close relationship between EBV infection and autoimmunization or autoimmune-like hepatitis.

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Authors and Affiliations

  1. Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan, , , , , , JP

    Kyoko Kojima, Ryozo Nagayama, Sachio Hirama, Tomomi Maeda, Hajime Takikawa, Kazuhiko Miyake & Masami Yamanaka

  2. Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan, , , , , , JP

    Junji Shiga

Authors
  1. Kyoko Kojima
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  2. Ryozo Nagayama
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  3. Sachio Hirama
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  4. Tomomi Maeda
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  5. Hajime Takikawa
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  6. Kazuhiko Miyake
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  7. Masami Yamanaka
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  8. Junji Shiga
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Received: October 16, 1998 / Accepted: June 25, 1999

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Kojima, K., Nagayama, R., Hirama, S. et al. Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly. J Gastroenterol 34, 706–712 (1999). https://doi.org/10.1007/s005350050324

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  • DOI: https://doi.org/10.1007/s005350050324

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