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Quality control for clinical islet transplantation: organ procurement and preservation, the islet processing facility, isolation, and potency tests

  • Topics
  • HBP treatment using cell transplantation in the near future
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Pancreatic islet transplantation has become one of the ideal treatments for patients with type 1 diabetes mellitus due to improvements in isolation techniques and immunosuppression regimens. In order to ensure the safety and rights of patients, isolated islets need to meet the criteria for regulation as both a biological product and a drug product. For the constant success of transplantation, therefore, all investigators involved in clinical islet transplantation must strive to ensure the safety, purity, and potency of islets in all the phases of clinical islet isolation and transplantation. In this review, we summarize the quality control for clinical islet isolation and transplantation, and the latest topics of pre-transplant islet assessment.

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Authors and Affiliations

  1. Department of Surgery, School of Medicine, Fujita Health University, Aichi, Japan

    Toshiyuki Yamamoto, Akihiko Horiguchi, Masahiro Ito, Hideo Nagata & Shuichi Miyakawa

  2. Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA

    Toshiyuki Yamamoto, Hirohito Ichii & Camillo Ricordi

Authors
  1. Toshiyuki Yamamoto
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  2. Akihiko Horiguchi
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  3. Masahiro Ito
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  4. Hideo Nagata
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  5. Hirohito Ichii
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  6. Camillo Ricordi
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  7. Shuichi Miyakawa
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Correspondence to Toshiyuki Yamamoto.

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Yamamoto, T., Horiguchi, A., Ito, M. et al. Quality control for clinical islet transplantation: organ procurement and preservation, the islet processing facility, isolation, and potency tests. J Hepatobiliary Pancreat Surg 16, 131–136 (2009). https://doi.org/10.1007/s00534-009-0064-z

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  • DOI: https://doi.org/10.1007/s00534-009-0064-z

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