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Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms

  • Review article
  • Published:
Journal of Hepato-Biliary-Pancreatic Surgery

Abstract

Hepatolithiasis is more frequently seen in East Asian countries than in Western countries, and it is well known to represent a high-risk state for intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma is an aggressive tumor that shows a dismal outcome even after resection. Cancer results from multistep carcinogenesis; however, the precise molecular mechanisms involved in the genetic alterations in cancer remain unknown. The accumulation of alterations in cancer-related genes leads to disruptions in cell-cycle regulation and also to continuous cell proliferation. The present review provides an overview of cancer-related genes in intrahepatic cholangiocarcinogenesis arising in hepatolithiasis. Further study of molecular mechanisms in hepatolithiasis-related intrahepatic cholangiocarcinoma, and the delineation of the influence of the genes involved should lead to our understanding of cholangiocarcinogenesis.

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Authors and Affiliations

  1. Department of Transplantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Tamotsu Kuroki, Yoshitsugu Tajima & Takashi Kanematsu

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  1. Tamotsu Kuroki
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  2. Yoshitsugu Tajima
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  3. Takashi Kanematsu
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Kuroki, T., Tajima, Y. & Kanematsu, T. Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms. J Hepatobiliary Pancreat Surg 12, 463–466 (2005). https://doi.org/10.1007/s00534-005-1004-1

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  • DOI: https://doi.org/10.1007/s00534-005-1004-1

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