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New thoughts on the pathobiology of regimen-related mucosal injury

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Abstract

Background

Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient’s mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors.

Conclusion

Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.

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Author information

Authors and Affiliations

  1. The Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA

    Lowell Anthony

  2. Department of Medicine, The University of Adelaide, Adelaide, South Australia, Australia

    Joanne Bowen

  3. Department of Medical Oncology, The Royal Adelaide Hospital, Adelaide, South Australia, Australia

    Joanne Bowen

  4. MD Anderson Cancer Center, Houston, TX, USA

    Adam Garden

  5. The Royal Melbourne Hospital, Victoria, Australia

    Ian Hewson

  6. Brigham and Women’s Hospital, Boston, MA, USA

    Stephen Sonis

Authors
  1. Lowell Anthony
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  2. Joanne Bowen
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  3. Adam Garden
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  4. Ian Hewson
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  5. Stephen Sonis
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Corresponding author

Correspondence to Stephen Sonis.

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Anthony, L., Bowen, J., Garden, A. et al. New thoughts on the pathobiology of regimen-related mucosal injury. Support Care Cancer 14, 516–518 (2006). https://doi.org/10.1007/s00520-006-0058-1

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  • DOI: https://doi.org/10.1007/s00520-006-0058-1

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