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How does your kidney smell? Emerging roles for olfactory receptors in renal function

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Abstract

Olfactory receptors (ORs) are chemosensors that are responsible for one’s sense of smell. In addition to this specialized role in the nose, recent evidence suggests that ORs are also found in a variety of additional tissues including the kidney. As this list of renal ORs continues to expand, it is becoming clear that they play important roles in renal and whole-body physiology, including a novel role in blood pressure regulation. In this review, we highlight important considerations that are crucial when studying ORs and present the current literature on renal ORs and their emerging relevance in maintaining renal function.

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Acknowledgments

The authors are grateful to Dr. Diego Rodriguez-Gil (Yale University) for a critical reading of portions of this manuscript and for valued insights and discussions, and to members of the Pluznick lab for helpful discussions.

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

Jennifer L. Pluznick: Carl W. Gottschalk Research Scholar Grant from the American Society of Nephrology

Blythe D. Shepard: National Institutes of Health (F32-DK096780).

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    Blythe D. Shepard & Jennifer L. Pluznick

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Correspondence to Jennifer L. Pluznick.

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Shepard, B.D., Pluznick, J.L. How does your kidney smell? Emerging roles for olfactory receptors in renal function. Pediatr Nephrol 31, 715–723 (2016). https://doi.org/10.1007/s00467-015-3181-8

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