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Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis

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Abstract

A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic differentiation 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type 1 (T1D) or type 2 (T2D). Fourteen case-control studies were analyzed, including genotype data on 3,057 patients with diabetes (T1D n=1,213, T2D n=1,844) and 2,446 controls. Overall and race-specific summary odds ratios (ORs) were obtained with fixed and random effects models. The Thr allele did not significantly increase the overall risk for T1D (OR 1.27 [0.94–1.71], P=0.12) or T2D (OR 1.07 [0.90–1.28], P=0.46). The Thr allele conferred increased susceptibility in subjects of Asian racial descent to T1D (OR 1.88 [1.10–3.21], P=0.020), but not to T2D (OR 1.08 [0.74–1.56], P=0.70). There was no association in subjects of European descent (OR 0.97 [0.76–1.23], P=0.80 for T1D; OR 1.03 [0.88–1.21], P=0.68 for T2D). Larger studies seemed to show more conservative estimates for the association with T1D (P=0.083). The Ala45Thr polymorphism of the NEUROD1 gene has no effect on susceptibility to T2D. It may however be a risk factor for susceptibility to T1D, in particular for subjects of Asian descent, although bias cannot be totally excluded.

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Acknowledgments

We are thankful to Dr. David Owerbach and Dr. Lars Hansen for providing us with additional data from their studies.

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Authors and Affiliations

  1. Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, 45110, Greece

    Fotini K. Kavvoura & John P. A. Ioannidis

  2. Biomedical Research Institute, Foundation for Research and Technology-Hellas, Ioannina, Greece

    John P. A. Ioannidis

  3. Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, USA

    John P. A. Ioannidis

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  1. Fotini K. Kavvoura
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  2. John P. A. Ioannidis
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Correspondence to John P. A. Ioannidis.

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Kavvoura, F.K., Ioannidis, J.P.A. Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis. Hum Genet 116, 192–199 (2005). https://doi.org/10.1007/s00439-004-1224-5

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  • DOI: https://doi.org/10.1007/s00439-004-1224-5

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