Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in regulation of eukaryotic gene expression. Aberrant expression and structural alternation of miRNAs are considered to participate in tumorigenesis and cancer development. Recently, different genotypes of miR-196a polymorphisms (SNP, rs11614913) were found to be associated with the survival of patients with lung cancer and increased risk of breast cancer. To further investigate whether this polymorphism may influence glioma risk or not, we examined the SNP allele frequency in Chinese population. Our data shows the genotype CC of miR-196a (rs11614913) polymorphism is associated with decreased risk of glioma in the Chinese population (OR = 0.74, 95% CI:0.56–0.98). Furthermore, a significant association was observed between this genotype and glioma risk in the subgroups of adult glioma (OR = 0.73, 95% CI:0.55–0.98), male glioma (OR = 0.69, 95% CI:0.48–0.99) and patients with glioblastoma (OR = 0.58, 95% CI:0.37–0.91). This was the first study investigating the association between the miR-196a rs11614913 and glioma risk. Compared with the results from previous studies in lung cancer and breast cancer, our data suggest a different genotype association in glioma. This may be related to the diversity on the tissue origin, tumor type, tumorigenesis, and developing process.
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Acknowledgments
This work was supported by National Natural Science Foundation of China (Project: 30700465). And was partially supported by Shanghai Science and Technology Research Program (09JC1402200), Natural Science Foundation of China (30800622) and Shanghai Subject Chief Scientist for Public Health 08GWD07. We thank all the patients and individuals for their participation, the clinicians and other hospital staff, cancer registries, and study staff. We thank Dr. Jianfeng Dai (Yale University) and Yaqiong Sun (Fudan University) for their expert assistance.
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T. Dou, Q. Wu and X. Chen are contributed equally to this work.
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Dou, T., Wu, Q., Chen, X. et al. A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population. J Cancer Res Clin Oncol 136, 1853–1859 (2010). https://doi.org/10.1007/s00432-010-0844-5
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DOI: https://doi.org/10.1007/s00432-010-0844-5