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Arterial intima-media thickening and endothelial dysfunction in obese Chinese children

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Abstract

We studied ultrasonographic signs of early atherosclerosis in relation to established risk factors of cardiovascular disease in 43 obese school-age children compared to 28 non-obese controls. The groups did not show significant differences in age, gender ratio and body height. Mean carotid intima-media-thickness (IMT), carotid haemodynamic parameters, flow-mediated dilatation of the brachial artery (FMD), and biochemical markers of dyslipidaemia were measured and correlated. IMT was significantly increased (0.62 mm vs. 0.46 mm, P <0.001) and FMD was markedly reduced (10.9% vs. 18.8%, P <0.001) in the obesity group. Differences in IMT and FMD persisted after adjustment for Body Mass Index (BMI) and blood pressure on ANCOVA. BMI was highly associated with increased IMT ( r =0.58, P <0.01) and reduced FMD ( r =-0.42, P <0.01), as were blood levels of total cholesterol, LDL cholesterol and Apo B. Conclusion:Childhood obesity seems to contribute to the development and progression of early atherosclerosis, particularly in combination with hypertension and dyslipidaemia. In order to prevent coronary atherosclerosis and other cardiovascular complications, it is vital to control obesity starting from childhood. Ultrasonography of the arterial wall may be used in a clinical setting to identify high-risk patients among severely obese children.

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Abbreviations

BMI :

body mass index

CCA :

common carotid artery

DBP :

diastolic blood pressure

FH :

familial hypercholesterolaemia

FMD :

flow-mediated dilatation

ICA :

internal carotid artery

IMT :

intima-media thickness

SBP :

systolic blood pressure

TC :

total cholesterol

TG :

total triglycerides

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Author notes

  1. Henning Neubauer

    Present address: , Shuangling Xincun 25-2-501, 310016 , Hangzhou, China

Authors and Affiliations

  1. Department of Cardiology, Children’s Hospital, Zhejiang University School of Medicine, 310003 , Hangzhou, China

    Weihua Zhu, Xianmei Huang, Mengxia Li & Henning Neubauer

  2. Department of Ultrasonography, Children’s Hospital, Zhejiang University School of Medicine, 310003 , Hangzhou, China

    Jin He

Authors
  1. Weihua Zhu
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  2. Xianmei Huang
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  3. Jin He
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  4. Mengxia Li
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  5. Henning Neubauer
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Correspondence to Henning Neubauer.

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Zhu, W., Huang, X., He, J. et al. Arterial intima-media thickening and endothelial dysfunction in obese Chinese children. Eur J Pediatr 164, 337–344 (2005). https://doi.org/10.1007/s00431-005-1642-y

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  • DOI: https://doi.org/10.1007/s00431-005-1642-y

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