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Paroxetine withdrawal in a neonate with historical and laboratory confirmation

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References

  1. Chambers CD, Johnson BA, Dick LM, Felix RJ, Jones KL (1996) Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 335: 1010–1015

    Article  CAS  PubMed  Google Scholar 

  2. Costei AM, Kozer E, Ho T, Ito S, Koren G (2002) Perinatal outcome following third trimester exposure to paroxetine. Arch Pediatr Adolesc Med 156: 1129–1132

    PubMed  Google Scholar 

  3. Dahl ML, Olhager E, Ahlner J (1997) Paroxetine withdrawal syndrome in a neonate (letter). Br J Psychiatry 171: 391–392

    CAS  Google Scholar 

  4. Gerola O, Fiocchi S, Rondini G (1999) Antidepressant therapy in pregnancy: a review from the literature and report of a suspected paroxetine withdrawal syndrome in a newborn. Rivista Italiana di Pediatria 25: 216–218

    Google Scholar 

  5. Hegerl U, Bottlender R, Gallinat J, Kuss HJ, Ackenheil M, Moller HJ (1998) The serotonin syndrome scale: first results on validity. Eur Arch Psychiatry Clin Neurosci 248: 96–103

    Article  CAS  PubMed  Google Scholar 

  6. Isbister GK, Dawson A, Whyte IM, Prior FH, Clancy C, Smith AJ (2001) Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome? Arch Dis Child Fetal Neonatal Ed 85: F147–F148

    CAS  Google Scholar 

  7. Kaye CM, Haddock RE, Langley PF, Mellows G, Tasker TC, Zussman BD et al (1989) A review of the metabolism and pharmacokinetics of paroxetine in man. Acta Psychiatr Scand Suppl 350: 60–75

    CAS  PubMed  Google Scholar 

  8. Martensson B, Wagner A, Beck O, Brodin K, Montero D, Asberg M (1991) Effects of clomipramine treatment on cerebrospinal fluid monoamine metabolites and platelet 3H-imipramine binding and serotonin uptake and concentration in major depressive disorder. Acta Psychiatr Scand 83: 125–133

    CAS  PubMed  Google Scholar 

  9. Mhanna MJ, Bennet JB, Izatt SD (1997) Potential fluoxetine chloride (Prozac) toxicity in a newborn (letter). Pediatrics 100: 158–159

    CAS  PubMed  Google Scholar 

  10. Nisijima K (2000) Abnormal monoamine metabolism in cerebrospinal fluid in a case of serotonin syndrome (letter). J Clin Psychopharmacol 20: 107–108

    Article  CAS  PubMed  Google Scholar 

  11. Price JS, Waller PC, Wood SM, MacKay AV (1996) A comparison of the post-marketing safety of four selective serotonin re-uptake inhibitors including the investigation of symptoms occurring on withdrawal. Br J Clin Pharmacol 42: 757–763

    CAS  PubMed  Google Scholar 

  12. Spencer MJ (1993) Fluoxetine hydrochloride (Prozac) toxicity in a neonate. Pediatrics 92: 721–722

    CAS  PubMed  Google Scholar 

  13. Stiskal JA, Kulin N, Koren G, Ho T, Ito S (2001) Neonatal paroxetine withdrawal syndrome. Arch Dis Child Fetal Neonatal Ed 84: F134–F135

    CAS  PubMed  Google Scholar 

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Acknowledgements

We thank the Institute of Neurology, London for doing the analysis on CSF and the Department of Toxicology, Royal Hallamshire Hospital, Sheffield, for assaying olanzapine and paroxetine concentrations in plasma.

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Authors and Affiliations

  1. Department of Neonatology, Royal Hallamshire Hospital, Sheffield, UK

    Sanjay Jaiswal & Robert C. Coombs

  2. Discipline of Clinical Pharmacology, University of Newcastle, Level 5 Clinical Sciences Building, Newcastle Mater Misericordiae Hospital, NSW 2298, Waratah , Australia

    Geoffrey K. Isbister

Authors
  1. Sanjay Jaiswal
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  2. Robert C. Coombs
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  3. Geoffrey K. Isbister
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Correspondence to Geoffrey K. Isbister.

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Jaiswal, S., Coombs, R.C. & Isbister, G.K. Paroxetine withdrawal in a neonate with historical and laboratory confirmation. Eur J Pediatr 162, 723–724 (2003). https://doi.org/10.1007/s00431-003-1293-9

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  • DOI: https://doi.org/10.1007/s00431-003-1293-9

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