Abstract
Lacosamide (LCM) is an antiepileptic drug (AED) that has demonstrated a good efficacy in controlling seizures as an add-on in adult epilepsy. To date, there have been no studies on LCM in patients with brain tumor-related epilepsy (BTRE). To evaluate efficacy and tolerability of LCM as an add-on in BTRE, we followed 14 patients suffering from BTRE who had already been treated with other AEDs and who had not experienced adequate seizure control. Eleven patients underwent chemotherapy while being treated with LCM. Mean duration of follow up was 5.4 months (min < 1 max 10 months). Mean seizure number in the last month prior to the introduction of LCM had been 15.4. At last follow-up, the mean seizure number was reduced to 1.9/month. Lacosamide mean dosage was of 332.1 mg/day (min 100 max 400 mg/day). Responder rate was 78.6%. One patient discontinued LCM because of side-effects. There were no other reported side-effects. Preliminary data on the use of LCM in add-on in patients with BTRE indicate that this drug may represent a valid alternative as an add-on in this particular patient population. However, larger samples are necessary in order to draw definitive conclusions.
References
van Breemen MSM, Rijsman RM, Taphoorn MJ, Walchenbach R, Zwinkels H, Vecht CJ (2009) Efficacy of anti-epileptic drugs in patients with gliomas and seizures. J Neurol 256:1519–1526
Vecht CJ, Van Breemen M (2006) Optimizing therapy of seizures in patients with brain tumors. Neurology 67(12 Suppl 4):S10–S13
Ben-Menachem E, Biton V, Jatuzis D, Abou-Khalil B, Doty P, Rudd GD (2007) Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Epilepsia 48:1308–1317
Kelemen A, Halász P (2010) Lacosamide for the prevention of partial onset seizures in epileptic adults. Neuropsychiatr Dis Treat 6:465–471
Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS (2009) Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res 83:1–43
Cross SA, Curran MP (2009) Lacosamide: in partial-onset seizures. Drugs 69:449–459
Beydoun A, D’Souza J, Hebert D, Doty P (2009) Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partial-onset seizures. Expert Rev Neurother 9:33–42
Newton HB, Connelly J, Lima J, Cunningham H, Pearl D, Malkin M (2010) Lacosamide in brain tumour patients with refractory seizures: efficacy and tolerability. J Neurol 25(Suppl 1):S1–S246 P476
Fisher RS, van Emde Boas W, Blume W et al (2005) Epileptic seizures and epilepsy: definitions proposed by the International league against epilepsy (ILAE) and the International bureau for epilepsy (IBE). Epilepsia 46:470–482
Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events v3.0, DCTD, NCI, NIH, DHHS, December 12, 2003. http://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcaev3.pdf
Taillibert S, Laigle-Donadey F, Sanson M (2004) Palliative care in patients with primary brain tumors. Curr Opin Oncol 16:587–592
Maschio M, Dinapoli L, Vidiri A et al (2009) The role side effects play in the choice of antiepileptic therapy in brain tumor-related epilepsy: a comparative study on traditional antiepileptic drugs versus oxcarbazepine. J Exp Clin Cancer Res 28:60
Maschio M, Dinapoli L, Zarabla A et al (2008) Outcome and tolerability of topiramate in brain tumor associated epilepsy. J Neurooncol 86:61–70
Maschio M, Albani F, Baruzzi A et al (2006) Levetiracetam therapy in patients with brain tumour and epilepsy. J Neurooncol 80:97–100
Novy J, Stupp R, Rossetti AO (2009) Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. Clin Neurol Neurosurg 111:171–173
Maschio M, Dinapoli L, Saveriano F et al (2009) Efficacy and tolerability of zonisamide as add-on in brain tumor-related epilepsy: preliminary report. Acta Neurol Scand 120:210–212
Pace A, Vidiri A, Galiè E et al (2003) Temozolomide chemotherapy for progressive low-grade glioma: clinical benefits and radiological response. Ann Oncol 14:1722–1726
Ngo L, Nei M, Glass J (2006) Temozolomide treatment of refractory epilepsy in a patient with an oligodendroglioma. Epilepsia 47:1237–1238
Maschio M, Dinapoli L, Sperati F et al (2010) Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life. J Neurooncol Nov 25 [Epub ahead of print]
Dinapoli L, Maschio M, Jandolo B et al (2009) Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study. Neurol Sci May 5 [Epub ahead of print]
Acknowledgments
The authors wish to express their gratitude to Ms. Lesley Pritikin for reviewing the manuscript.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Maschio, M., Dinapoli, L., Mingoia, M. et al. Lacosamide as add-on in brain tumor-related epilepsy: preliminary report on efficacy and tolerability. J Neurol 258, 2100–2104 (2011). https://doi.org/10.1007/s00415-011-6132-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-011-6132-8