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5-ht2c receptor and mao-a interaction analysis: no association with suicidal behaviour in bipolar patients

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Abstract

The serotonin 2C (HTR2C) receptor has been implicated in suicide-related behaviours, however there are not many studies to date about HTR2C and suicidality. We studied HTR2C haplotypes in suicide attempters, where our sample composed of 306 families with at least one member affected by bipolar disorder. HTR2C (Cys23Ser and a common STR in the promoter) variants were analyzed with respect to attempter status and the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.

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Acknowledgments

This work was made possible through the support of the Canadian Institutes for Health Research (CIHR), and the National Alliance for Research in Schizophrenia and Depression (NARSAD). VDL is a CIHR Fellow and NARSAD Young Investigator. VDL is supported by a Pilot Grant from the American Foundation for Suicide Prevention.

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Authors and Affiliations

  1. Dept. of Psychiatry, University of Toronto, 250 College Street, R-30, M5T 1R8, Toronto, ON, Canada

    Vincenzo De Luca, Subi Tharmaligam, John Strauss & James L. Kennedy

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  1. Vincenzo De Luca
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  2. Subi Tharmaligam
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  3. John Strauss
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  4. James L. Kennedy
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Correspondence to Vincenzo De Luca.

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Drs. De Luca and Tharmaligam have contributed equally to this work.

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De Luca, V., Tharmaligam, S., Strauss, J. et al. 5-ht2c receptor and mao-a interaction analysis: no association with suicidal behaviour in bipolar patients. Eur Arch Psychiatry Clin Neurosc 258, 428–433 (2008). https://doi.org/10.1007/s00406-008-0815-x

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  • DOI: https://doi.org/10.1007/s00406-008-0815-x

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