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The septum pellucidum and its variants

An MRI study

  • ORIGINAL PAPER
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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract.

Purpose:

Increased prevalence of cavum septi pellucidi (CSP) in schizophrenic patients in comparison to healthy subjects was reported previously. Our purpose was to evaluate the prevalence of variants of the septum pellucidum in healthy subjects in three different age groups.

Methods:

151 healthy subjects, including 46 children (age 6 ± 4 years), 72 young adults (age 31 ± 8 years) and 33 elderly adults (age 59 ± 7 years) were examined with high-resolution MRI. Three observers analysed the images using a standardised protocol. We evaluated the incidences of CSP, cavum vergae (CV) and their length.

Results:

CSP was detected in 80% of the cases in the paediatric group and 68% of young adults and in 72% of the elderly adults. A cavum vergae (CV) was noted in 22% of the children, in 39% of the young adults and in 36% of the elderly subjects. There was no significant difference between the age-related groups.

Conclusion:

We detected a high prevalence of cavum septi pellucidi without a significant age dependence. Enlarged cava septi pellucidi are rare in healthy subjects.

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References

  1. Scott TF, Price TP, George MS, Brillman J, Rothfus W (1993) Cerebral malformations and schizophrenia. J Neuropsychiatry Clin Neuroscience 5:287–293

    CAS  Google Scholar 

  2. Swayze VW II, Andreasen NC, Ehrhardt JC, Yuh WTC, Alliger RJ, Cohen G (1990) Developmental abnormalities of the corpus callosum in schizophrenia. Arch Neurol 47:805–808

    PubMed  Google Scholar 

  3. Nopoulos PC, Flaum M, Andreasen NC, Swayze VW II (1995) Gray matter heterotopias in schizophrenia. Psychiatry Res 61:11–14

    CAS  PubMed  Google Scholar 

  4. Degreef G, Bogerts B, Falkai P, Greve B, Lantos G, Ashtari M, Liebermann J (1991) Increased prevalence of the cavum septum pellucidum in magnetic resonance scans and post-mortem brains of schizophrenic patients. Psychiatry Res: Neuroimaging 45:1–13

    Article  Google Scholar 

  5. Degreef G, Lantos G, Bogerts B, Ashtari M, Liebermann J (1992) Abnormalities of the septum pellucidum on MR scans in first-period of schizophrenic patients. Am J Neuroradiol 13:835–840

    CAS  PubMed  Google Scholar 

  6. De Lisi E, Hoff AL, Kushner M, Degreef G (1993) Increased prevalence of cavum septum pellucidum in schizophrenia. Psychiatry Res: Neuroimaging 1993:193–199

    Article  Google Scholar 

  7. Shiori T, Oshitani Y, Kato T, Murashita J, Hamakawa H, Inubushi T, Nagata T, Takahashi S (1996) Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia. Psychol Med 26:431–434

    PubMed  Google Scholar 

  8. Hagino H, Suzuki M, Kurokawa K,Mori K, Nohara S, Takahashi T, Yamashita I, Yotsutsuji T, Kurachi M, Seto H (2001) Magnetic Resonance Imaging Study of the Cavum Septi Pellucidi in Patients With Schizophrenia. Am J Psychiatry 158:1717–1719

    Article  CAS  PubMed  Google Scholar 

  9. Filipovic B, Teofilovski-Parapid G (1998) Ageing changes of morphological characteristics of cavum septi pellucidi in adults: a dissectional study. Ital J Anat Embryol 103(2):107–116

    PubMed  Google Scholar 

  10. Dandy WE (1932) Congenital cerebral cysts of the cavum septi pellucidi (fifth ventricle) and cavum vergae (sixth ventricle). Diagnosis and treatment. Arch Neurol Psychiatry 25:44–66

    Google Scholar 

  11. Schwidde TJ (1952) Incidence of cavum septi pellucidi and cavum vergae in 1032 human brains. Arch Neurol Psychiatry 67:625–632

    CAS  Google Scholar 

  12. O’Rahilly R, Müller F (1992) The Telencephalon. In: Human embryology and teratology. New York, Wiley-Liss. Inc, pp 272–277

  13. Hochstetter F (1919) Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns. Wien, Deutike 176

  14. Rakic P, Yakovlev PI (1968) Development of the corpus callosum and cavum septi in man. J Comp Neurol 132:45–72

    CAS  PubMed  Google Scholar 

  15. Pfluger T, Weil S, Vollmar C, Heiss D, Egger J, Scheck R, Hahn K (1999) Normative volumetric data of the developing hippocampus in children based on magnetic resonance imaging. Epilepsia 40:414–423

    CAS  PubMed  Google Scholar 

  16. Nopoulos P, Krie A, Andreasen NC (2000) Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates. J Neuropsychiatry Clin Neurosci 12(3):344–349

    Article  CAS  PubMed  Google Scholar 

  17. Andreasen N, Nasrallah HA, Dunn V, et al. (1986) Structural abnormalities in the frontal system in schizophrenia. Arch Gen Psychiatry 43:136–144

    CAS  PubMed  Google Scholar 

  18. Bloom F (1993) Advancing a neurodevelopmental origin for schizophrenia. Arch Gen Psychiatry 50:224–227

    CAS  PubMed  Google Scholar 

  19. De Lisi LE, Liebermann J (1993) Longitudinal perspectives on the pathophysiology of schizophrenia: Examining the neurodevelopmental versus neurodegenerative hypotheses. Psychiatry Res Neuroimaging 139:147–150

    Google Scholar 

  20. Murray RB, O’Callaghan E, Castle DJ, Lewis SW (1992) A neurodevelopmental approach to the classification of schizophrenia. Schizophr Bull 182:319–332

    Google Scholar 

  21. Bigelow LB, Nasrallah HA, Rauscher FP (1983) Corpus callosum thickness in chronic schizophrenia. Br J Psychiatry 142:284–287

    CAS  PubMed  Google Scholar 

  22. Nopoulos P, Swayze V, Andreasen NC (1996) Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidum. J Neuropsychiatry Clin Neurosci 8:147–152

    CAS  PubMed  Google Scholar 

  23. Andreasen NC, Smith MR, Jacoby CG, Dennert JW, Olsen SA (1982) Ventricular enlargement in schizophrenia. Definition and prevalence. Am J Psychiatry 139:292–296

    CAS  PubMed  Google Scholar 

  24. Weinberger DR, Bigelow LB, Kleinman JE, Klein ST, Rosenblatt JE, Wyatt RJ (1980) Cerebral ventricular enlargement in chronic schizophrenia: An association with poor response to treatment. Arch Gen Psychiatry 37:11–13

    CAS  PubMed  Google Scholar 

  25. Rauschning W (1994) Brain tumours and tumour-like masses: classification and differential diagnosis. In: Osborn AG (ed) Diagnostic neuroradiology. Mosby Yearbook, pp 422–426

  26. Bodensteiner JB (1995) The saga of the septum pellucidum: a tale of unfounded clinical investigations. L Child Neurol 10:227–231

    CAS  Google Scholar 

  27. Spillane JD (1962) Five boxers. BMJ ii:1205–1210

    Google Scholar 

  28. Corsellis JAN (1989) Boxing and the brain. BMJ 298:105–109

    CAS  PubMed  Google Scholar 

  29. Moseley IF (2000) The neuroimaging evidence for chronic brain damage due to boxing. Neuroradiology 42:1–8

    Article  CAS  PubMed  Google Scholar 

  30. Shaw CM, Alvord EC (1969) Cavum septi pellucidi et vergae: Their normal and pathological states. Brain 92:213–224

    CAS  PubMed  Google Scholar 

  31. Nakano S, Hojo H, Kataoka K, Ramasak S (1981) Age related incidence of cavum septi pellucidi and cavum vergae on CT scans of paediatric patients. J Comput Assist Tomogr 5:348–349

    CAS  PubMed  Google Scholar 

  32. Sarwar M (1989) The septum pellucidum: Normal and abnormal. Am J Neuroradiol 989–1005

    Google Scholar 

  33. Schaefer GB, Bodensteiner JB, Thompson JN (1994) Subtle anomalies of the septum pellucidum and neurodevelopmental deficits. Dev Med Child Neurol 36:554–559

    CAS  PubMed  Google Scholar 

  34. Renier D, Arnaud E, Cinalli G, Sebag G, Zerah M, Marchac D (1996) Prognosis of mental function in Apert’s syndrome. J Neurosurg 85:66–72

    CAS  PubMed  Google Scholar 

  35. Barkovich AJ, Fram EK,Norman D (1989) Septo-optic dysplasia: MR imaging. Radiology 171:189–192

    CAS  PubMed  Google Scholar 

  36. Barkovich AJ, Norman D (1989) Absence of the septum pellucidum: a useful sign in the diagnosis of congenital brain malformations. Am J Roentgenol 152:353–360

    CAS  Google Scholar 

  37. Supprian T, Heils A, Hofmann E, Warmuth-Metz M, Solymosi L (1999) Isolated absence of the septum pellucidum. Neuroradiology 41:563–566

    Article  CAS  PubMed  Google Scholar 

  38. Jurjus GJ, Nasrallah HA, Olsen SC, Schwarzkopf SB (1993) Cavum septum pellucidum in schizophrenia, affective disorders and healthy controls. A magnetic resonance imaging study. Psychol Med 23:319–322

    CAS  PubMed  Google Scholar 

  39. Nopoulos P, Swayze V, Flaum M, Ehrhardt JC, Yuh WTC, Andreasen NC (1997) Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging. Biol Psychiatry 41:1102–1108

    Article  CAS  PubMed  Google Scholar 

  40. Van Wagenen WP, Aird RB (1934) Dilatations of the cavity of the septum pellucidum and cavum vergae. Am J Cancer 23:539–557

    Google Scholar 

  41. Hughes RA, Kemohan JW, Winchell MK (1955) Caves and cysts of the septum pellucidum. Arch Neurol Psychiatry 74:259–266

    CAS  Google Scholar 

  42. Shunk H (1963) Congenital dilatations of the septum pellucidum. Radiology 81:610–618

    Google Scholar 

  43. Nopoulos PC, Jay N, Andreasen NC, Rapaport JL (1998) Frequency and severity of enlarged cavum septi pellucidi in childhood-onset schizophrenia. Am J Psychiatry 155:1074–1079

    CAS  PubMed  Google Scholar 

  44. Lewis SW, Mezey GC (1985) Clinical correlates of septum pellucidum cavities: An unusual association with psychosis. Psychol Med 15:43–54

    CAS  PubMed  Google Scholar 

  45. Schwidde JT (1952) Incidence of cavum septi pellucidi et vergae in 1,032 human brains. Arch Neurol Psychiatry 67:625–633

    CAS  Google Scholar 

  46. Swayze VW II, Andreasen NC, Alliger RJ, Ehrhardt JC, Yuh WT (1990) Structural brain abnormalities in bipolar affective disorder. Ventricular enlargement and focal signal hyperintensities. Arch Gen Psychiatry 47:1054–1059

    PubMed  Google Scholar 

  47. Bogerts B, Ashtari M, Degreef G, Alvi RJ, Bilder R, Liebermann J (1990) Reduced temporal limbic structure volumes on magnetic resonance imaging in first episode schizophrenia. Psychiatry Res Neuroimaging 35:1–13

    Article  CAS  Google Scholar 

  48. Suddath RL, Casanova MF, Goldberg TE, Daniel DG, Kelsoe JR, Weinberger DR (1989) Temporal lobe pathology in schizophrenia. A quantitative magnetic resonance imaging study. Am J Psychiatry 146:464–472

    CAS  PubMed  Google Scholar 

  49. Larroche JC, Baudey J (1962) Cavum septi pellucidi, cavum vergae, cavum veli interpositi: Cavities de la ligne mediane. Etude anatomique et pneumoencephalographique dans la période neonatale. Biologia Neonate 3:193–236

    Google Scholar 

  50. Kocer N, Kantarci E, Mihmalh I, Islak C, Cokyüksel O (2000) Spontaneous regression of a cyst of the cavum septi pellucidi. Neuroradiology 42:360–362

    Article  CAS  PubMed  Google Scholar 

  51. Bruyn GW (1997) Agenesis septi pellucidi,cavum septi pellucidi, cavum vergae and cavum veli interpositi. In: Vinken Pf, Bruyn GW (eds) Handbook of clinical neurology, Vol. 30, Amsterdam, Elsevier pp 299–336

  52. Nakano S, Hojo H, Kataoka K,Yamasaki S (1981) Age related incidence of cavum septi pellicidi and cavum vergae on CT scans of pedriatic patients. Comput Assist Tomogr 5:348–349

    CAS  PubMed  Google Scholar 

  53. Aldur MM, Gurcan F, Basar R, Aksit MD (1999) Frequency of septum pellucidum anomalies in non-psychotic population: a magnetic resonance imaging study. Surg Radiol Anat 21(2):119–123

    CAS  PubMed  Google Scholar 

  54. Oterruelo FT (1986) On the cavum septi pellucidi and the cavum vergae. Anat Anz 162(4):271–278

    PubMed  Google Scholar 

  55. Auer RN, Gilbert JJ (1982) Cavum vergae without cavum septi pellucidi. Arch Pathol Lab Med 106(9):462–463

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute for Clinical Radiology, University Munich, Ziemssenstraße 1, 80336, Munich, Germany

    Christine M. Born MD, Maximilian Reiser MD, H. J. Möller & Gerda L. Leinsinger MD

  2. Dept. of Psychiatry, University Munich, Nußbaumstraße 7, 80336, Munich, Germany

    Eva M. Meisenzahl MD & Thomas Frodl MD

  3. Dept. of Nuclear Medicine, University Munich, Ziemssenstraße 1, 80336, Munich, Germany

    Thomas Pfluger MD

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  1. Christine M. Born MD
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  2. Eva M. Meisenzahl MD
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  3. Thomas Frodl MD
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  4. Thomas Pfluger MD
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  5. Maximilian Reiser MD
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  6. H. J. Möller
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  7. Gerda L. Leinsinger MD
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Correspondence to Gerda L. Leinsinger MD.

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Born, C.M., Meisenzahl, E.M., Frodl, T. et al. The septum pellucidum and its variants. European Archives of Psychiatry and Clinical Neurosciences 254, 295–302 (2004). https://doi.org/10.1007/s00406-004-0496-z

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  • DOI: https://doi.org/10.1007/s00406-004-0496-z

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