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Efficacy of low-dose hCG in late follicular phase in controlled ovarian stimulation using GnRH agonist protocol

  • Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

Safe, simple and cost-effective protocol is an important goal in ART cycles. The aim of this prospective study was whether administration of low-dose hCG in late follicular phase can be used clinically to replace gonadotropin administration in GnRH long protocol.

Materials and methods

122 patients who were candidates for ART enrolled the study and randomly divided into two groups. The control group (n = 62) received standard long protocol and gonadotropin administration continued until the day of hCG injection (10,000 IU) for final follicular maturation. The study group (n = 60) received GnRH long protocol and when at least ≥6 follicles with mean diameter ≥12 mm were observed in both ovaries, hMG was displaced by 200 IU per day of hCG until final follicular maturation.

Results

There were no significant differences in age, basal FSH, infertility duration and infertility etiology between two groups. There were no statistically significant differences between two groups regarding chemical pregnancy, clinical pregnancy, ongoing pregnancy, and abortion per cycle (50, 40, 40, and 20 % in study group vs. 45.2, 35.5, 35.5, and 21.4 % in control group, respectively). Mean dose of used gonadotropins was significantly higher in control group than that in the study group (2,524 ± 893 IU in control group and 1,439 ± 433 IU in study group) (p = 0.000).

Conclusion

According to our data, we recommend the use of low-dose hCG in GnRH long protocol because of lower doses of used gonadotropins.

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Acknowledgments

This project was funded by Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Conflict of interest

The authors have no conflicts of interest.

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Authors and Affiliations

  1. Departmant of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Av., Safayeh, Po Box 89195999, 8916877391, Yazd, Iran

    Abbas Aflatoonian, Fariba Yousefnejad, Maryam Eftekhar & Farnaz Mohammadian

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  1. Abbas Aflatoonian
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  2. Fariba Yousefnejad
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  3. Maryam Eftekhar
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  4. Farnaz Mohammadian
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Correspondence to Maryam Eftekhar.

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Aflatoonian, A., Yousefnejad, F., Eftekhar, M. et al. Efficacy of low-dose hCG in late follicular phase in controlled ovarian stimulation using GnRH agonist protocol. Arch Gynecol Obstet 286, 771–775 (2012). https://doi.org/10.1007/s00404-012-2337-z

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  • DOI: https://doi.org/10.1007/s00404-012-2337-z

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