Skip to main content

Advertisement

SpringerLink
Log in

KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Primary small cell carcinoma of the endometrium is very rare, and there have been no reports on KIT and PDGFRA in endometrial small cell carcinoma.

Case report

An 87-year-old woman was admitted to our hospital because of genital bleeding. Endometrial cytology and biopsy revealed small cell carcinoma. Scrutiny of the body showed stage III endometrial carcinoma with metastases. An immunohistochemical study of the biopsy specimens revealed positive reactions for synaptophysin, CD56, KIT, and PDGFRA, and negative reactions for cytokeratins, neuron-specific enolase, and chromogranin. A molecular genetic analysis using PCR-direct sequencing identified no mutations of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes. The patient received chemotherapy and radiation, but showed a downhill course, and died of carcinomatosis 6 months after the initial presentation.

Conclusion

The present case is the first reported case of primary small cell carcinoma of the endometrium with an examination of KIT and PDGFRA expressions and KIT and PDFGRA gene mutations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Huntsman DG, Clements PB, Gilks CB, Scully RE (1994) Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases. Am J Surg Pathol 18:364–375

    Article  CAS  PubMed  Google Scholar 

  2. van Hoeven KH, Hudock JA, Woodruff JM, Suhrland MJ (1995) Small cell neuroendocrine carcinoma of the endometrium. Int J Gynecol Pathol 14:21–29

    Article  PubMed  Google Scholar 

  3. Varras M, Akrivis Ch, Demou A, Hadjopoulos S, Antoniou N (2002) Primary small-cell carcinoma of the endometrium: clinicopathologic study of a case and review of the literature. Eur J Gynecol Oncol 23:577–581

    CAS  Google Scholar 

  4. Albores-Saavedra J, Martinez-Benitez B, Luevano E (2008) Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. Int J Gynecol Pathol 27:333–339

    Article  PubMed  Google Scholar 

  5. LaPoint RJ, Bourne PA, Wang HL, Xu H (2007) Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Appl Immunohistochem Mol Morphol 15:401–406

    Article  CAS  PubMed  Google Scholar 

  6. Lopes-Martin A, Ballenstin C, Garcia-Carbonero R, Castano A, Lopez-Rios F, Lopes-Encuentra A, Sanchez-Cespedes M, Castellano D, Bartolomes A, Cortes Funes H, Paz-Ares L (2007) Prognostic value of KIT expression in small cell lung carcinoma. Lung Cancer 56:405–413

    Article  Google Scholar 

  7. Micke P, Basral M, Faldum A, Bittinger F, Ronnstrand L, Blaukat A, Beeh KM, Oesch F, Fischer B, Buhl R, Hengstler JG (2003) Characterization of c-kit expression in small cell lung carcinoma: prognostic and therapeutic implications. Clin Cancer Res 9:188–194

    CAS  PubMed  Google Scholar 

  8. Camps C, Sirera R, Bremnes RM, Garde J, Safont MJ, Blasco A, Berrocal A, Sanchez JJ, Calabuig C, Marrorell M (2006) Analysis of c-kit expression in small cell lung carcinoma: prevalence and prognostic implications. Lung Cancer 52:343–347

    Article  PubMed  Google Scholar 

  9. Rossi G, Cavazza A, Marchioni A, Miggaldi M, Bavierli M, Fracciolongo N, Petruzzelli S, Longo L, Tamberi S, Crino L (2003) KIT expression in small cell carcinoma of the lung: effects of chemotherapy. Mod Pathol 16:1041–1047

    Article  PubMed  Google Scholar 

  10. Naeem M, Dahiya M, Clark JI, Creech SD, Alkin S (2002) Analysis of c-kit protein expression in small-cell lung carcinoma and its implications for prognosis. Hum Pathol 33:1182–1187

    Article  CAS  PubMed  Google Scholar 

  11. Mojica WD, Saxena R, Starostik P, Cheney RT (2005) CD117+ small cell lung cancer lacks the asp 816 val point mutation in exon 17. Histopathology 47:517–522

    Article  CAS  PubMed  Google Scholar 

  12. Boldrini L, Ursino S, Gisfredi S, Faviana P, Donati V, Camcci T, Lucchi M, Mussi A, Basolo F, Pingitore R, Fontanini G (2004) Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance. Clin Cancer Res 15:4101–4108

    Article  Google Scholar 

  13. Burger H, Den Bakker MA, Stoter G, Verweij J, Nooter K (2003) Lack of c-kit exon 11 activating mutations in c-kit/CD117-positive SCLC tumor specimens. Eur J Cancer 39:793–799

    Article  CAS  PubMed  Google Scholar 

  14. Sihto H, Sarlomo-Rikara M, Tynnienen O, Tanner M, Andersson LC, Franssila K, Nupponen NN, Joensuu H (2005) KIT and platelet-derived growth factor receptor alpha tyrosine kinase gene mutations and KIT amplifications in human solid tumors. J Clin Oncol 23:49–57

    Article  CAS  PubMed  Google Scholar 

  15. Hirota S, Isozaki K (2006) Pathology of gastrointestinal stromal tumor. Pathol Int 56:1–9

    Article  CAS  PubMed  Google Scholar 

  16. Losota J, Miettinen M (2006) KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs). Semin Diang Pathol 23:91–101

    Article  Google Scholar 

  17. Miettinen M, Lasota J (2006) Gastrointestinal stromal tumor: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med 130:1466–1478

    CAS  PubMed  Google Scholar 

  18. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shimomura Y, Kitamura Y (1998) Gain-of-function mutations of c-kit in human gastrointestinal stromal tumor. Science 279:577–580

    Article  CAS  PubMed  Google Scholar 

  19. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, Kitamura Y (2003) Gain-of-function mutations of platelet-derived growth factor receptor alpha gene in gastrointestinal stromal tumor. Gastroenterology 125:660–667

    Article  CAS  PubMed  Google Scholar 

  20. Miettinen M, Lasota J (2005) KIT (CD117): a review on expression in normal and neoplastic tissue, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 13:205–220

    Article  CAS  PubMed  Google Scholar 

  21. Terada T, Kawaguchi M, Furukawa K, Sekido Y, Osamura Y (2002) Minute mixed ductal-endocrine carcinoma of the pancreas with predominant intraductal growth. Pathol Int 52:740–746

    Article  PubMed  Google Scholar 

  22. Terada T, Kawaguchi M (2005) Primary clear cell adenocarcinoma of the peritoneum. Tohoku J Exp Med 271:271–275

    Article  Google Scholar 

  23. Terada T (2009) Gastrointestinal stromal tumor of the uterus: a case report with genetic analyses of c-kit and PDGFRA genes. Int J Gynecol Oncol 28:29–34

    Google Scholar 

  24. Terada T (2009) Primary extragastrointestinal stromal tumor of the transverse mesocolon without c-kit mutations but with PDGFRA mutations. Med Oncol 26:233–237

    Article  PubMed  Google Scholar 

  25. Terada T (2008) Primary multiple extragastrointestinal stromal tumors of the omentum with different mutations of c-kit gene. Would J Gastroenterol 14:7256–7259

    Article  CAS  Google Scholar 

  26. Terada T (2009) Mediastinal seminoma with multiple KIT gene mutations. Pathology 41:695–697

    Article  CAS  PubMed  Google Scholar 

  27. Slomovitz BM, Broaddus RR, Schmandt R, Wu W, Oh JC, Ramondetta LM, Burke TW, Gershenson DM, Lu KH (2004) Expression of imatinib mesylate-targeted kinase in endometrial carcinoma. Gynecol Oncol 95:32–36

    Article  CAS  PubMed  Google Scholar 

  28. Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE, Pasha TL, Salscheider M, Zhang PJ (2003) C-kit immunoreactivity in endometrial adenocarcinoma and its clinicopathologic significance. Int J Gynecol Pathol 22:149–155

    Article  PubMed  Google Scholar 

Download references

Conflict of interest statement

The author declares no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231, Shimizu-Ku, Shizuoka, 424-8636, Japan

    Tadashi Terada

Authors
  1. Tadashi Terada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tadashi Terada.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Terada, T. KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes. Arch Gynecol Obstet 282, 413–416 (2010). https://doi.org/10.1007/s00404-009-1324-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-009-1324-5

Keywords

Search

Navigation