References
Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H,Wollert KC (2006) The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res 98:351–360
Hsiao EC, Koniaris LG, Zimmers-Koniaris T, Sebald SM, Huynh TV, Lee SJ (2000) Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Mol Cell Biol 20:3742–3751
Clerk A, Kemp TJ, Zoumpoulidou G, Sugden PH (2007) Cardiac myocyte gene expression profiling during H2O2- induced apoptosis. Physiol Genomics 29:118–127
Buitrago M, Lorenz K,Maass AH,Oberdorf- Maass S, Keller U, Schmitteckert EM, Ivashchenko Y, Lohse MJ, Engelhardt S (2005) The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Nat Med 11:837–844
Xu J,Kimball TR,Lorenz JN,Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD (2006) GDF15/ MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res 98:342–350
Bootcov MR, Bauskin AR, Valenzuela SM,Moore AG, Bansal M,He XY, Zhang HP, Donnellan M, Mahler S, Pryor K, Walsh BJ,Nicholson RC,Fairlie WD,Por SB, Robbins JM, Breit SN (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA 94:11514–11519
Bottner M, Suter-Crazzolara C, Schober A, Unsicker K (1999) Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor- 15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell Tissue Res 297:103–110
Schober A, Bottner M, Strelau J, Kinscherf R, Bonaterra GA, Barth M, Schilling L, Fairlie WD, Breit SN, Unsicker K (2001) Expression of growth differentiation factor-15/macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain. J Comp Neurol 439:32–45
Schulz R, Kelm M,Heusch G (2004) Nitric oxide in myocardial ischemia/ reperfusion injury. Cardiovasc Res 61:402–413
Kempf T, Horn-Wichmann R, Brabant G, Peter T, Allhoff T,Klein G, Drexler H, Johnston N, Wallentin L, Wollert KC (2007) Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay. Clin Chem 53:284–291
Wollert KC, Kempf T, Peter T, Olofsson S, James S, Johnston N,Lindahl B,Horn- Wichmann R, Brabant G, Simoons ML, Armstrong PW, Califf RM, Drexler H, Wallentin L (2007) Prognostic value of growth-differentiation factor-15 in patients with non-ST-segment elevation acute coronary syndrome. Circulation 115:962–971
Kempf T, von Haehling S, Peter T, Allhoff T, Cicoira M, Doehner W, Ponikowski P, Filippatos GS, Rozentryt P, Drexler H, Anker SD, Wollert KC (2007) Prognostic utility of growth-differentiation factor-15 in patients with chronic heart failure. J Am Coll Cardiol (in press)
de Lemos JA,McGuire DK,Drazner MH (2003) B-type natriuretic peptide in cardiovascular disease. Lancet 362:316–322
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wollert, K.C. Growth-differentiation factor-15 in cardiovascular disease. Basic Res Cardiol 102, 412–415 (2007). https://doi.org/10.1007/s00395-007-0662-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00395-007-0662-3